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DAGLA

GENERAL INFORMATION

Gene name

 DAGLA

Gene description

 Diacylglycerol lipase, alpha

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Mixed
FANTOM5:Mixed

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in several tissues, most abundant in CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA062497
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed

GENE INFORMATION

Gene name

 DAGLA (HGNC Symbol)

Synonyms

 C11orf11, DAGLALPHA, KIAA0659, NSDDR

Description

 Diacylglycerol lipase, alpha (HGNC Symbol)

Entrez gene summary

 This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

Chromosome

 11

Cytoband

 q12.2

Chromosome location (bp)

 61680433 - 61747001

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134780 (version 83.38)

Entrez gene

 747

UniProt

 Q9Y4D2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y4D2

Antibodypedia

 DAGLA antibodies

PROTEIN BROWSER
DAGLA-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DAGLA-001
ENSP00000257215
ENST00000257215
Q9Y4D2 [Direct mapping]
Sn1-specific diacylglycerol lipase alpha
A0A024R517 [Target identity:100%; Query identity:100%]
Chromosome 11 open reading frame 11, isoform CRA_b
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
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GO:0005886 [plasma membrane]
GO:0006629 [lipid metabolic process]
GO:0007405 [neuroblast proliferation]
GO:0007596 [blood coagulation]
GO:0016021 [integral component of membrane]
GO:0016298 [lipase activity]
GO:0019369 [arachidonic acid metabolic process]
GO:0022008 [neurogenesis]
GO:0030168 [platelet activation]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0043196 [varicosity]
GO:0046340 [diacylglycerol catabolic process]
GO:0046872 [metal ion binding]
GO:0071926 [endocannabinoid signaling pathway]
GO:0098588 [bounding membrane of organelle]
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 1042 aa
115 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.