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GIF

GENERAL INFORMATION

Gene name

 GIF

Gene description

 Gastric intrinsic factor (vitamin B synthesis)

Protein class

 Disease related genes
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enriched (stomach cancer)
HPA (cell line):Not detected
HPA (normal tissue):Tissue enriched (stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Highly selective expression in cytoplasm of parietal cells in stomach.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA039908 , HPA040774
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enriched (stomach cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA039908
HPA040774

GENE INFORMATION

Gene name

 GIF (HGNC Symbol)

Synonyms

 IF, IFMH, INF, TCN3

Description

 Gastric intrinsic factor (vitamin B synthesis) (HGNC Symbol)

Entrez gene summary

 This gene is a member of the cobalamin transport protein family. It encodes a glycoprotein secreted by parietal cells of the gastric mucosa and is required for adequate absorption of vitamin B12. Vitamin B12 is necessary for erythrocyte maturation and mutations in this gene may lead to congenital pernicious anemia. [provided by RefSeq, Jul 2008]

Chromosome

 11

Cytoband

 q12.1

Chromosome location (bp)

 59829268 - 59845501

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134812 (version 83.38)

Entrez gene

 2694

UniProt

 P27352 (UniProt - Evidence at protein level)

neXtProt

 NX_P27352

Antibodypedia

 GIF antibodies

PROTEIN BROWSER
GIF-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GIF-001
ENSP00000257248
ENST00000257248
P27352 [Direct mapping]
Gastric intrinsic factor
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005768 [endosome]
GO:0005902 [microvillus]
GO:0006766 [vitamin metabolic process]
GO:0006767 [water-soluble vitamin metabolic process]
GO:0006824 [cobalt ion transport]
GO:0009235 [cobalamin metabolic process]
GO:0015889 [cobalamin transport]
GO:0016324 [apical plasma membrane]
GO:0031419 [cobalamin binding]
GO:0043202 [lysosomal lumen]
GO:0044281 [small molecule metabolic process]
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 417 aa
45.4 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.