Fields »
ABOUT
HELP
BLOG
DHX34

GENERAL INFORMATION

Gene name

 DHX34

Gene description

 DEAH (Asp-Glu-Ala-His) box polypeptide 34

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA042159 , HPA043558
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042159
HPA043558

GENE INFORMATION

Gene name

 DHX34 (HGNC Symbol)

Synonyms

 DDX34, KIAA0134

Description

 DEAH (Asp-Glu-Ala-His) box polypeptide 34 (HGNC Symbol)

Entrez gene summary

 DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this DEAD box protein family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a member of this family. It is mapped to the glioma 19q tumor suppressor region and is a tumor suppressor candidate gene. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 q13.32

Chromosome location (bp)

 47349281 - 47382704

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134815 (version 83.38)

Entrez gene

 9704

UniProt

 Q14147 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14147

Antibodypedia

 DHX34 antibodies

PROTEIN BROWSER
DHX34-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DHX34-001
ENSP00000331907
ENST00000328771
Q14147 [Direct mapping]
Probable ATP-dependent RNA helicase DHX34
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
GO:0000956 [nuclear-transcribed mRNA catabolic process]
GO:0003676 [nucleic acid binding]
GO:0004004 [ATP-dependent RNA helicase activity]
GO:0004386 [helicase activity]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0006396 [RNA processing]
GO:0016020 [membrane]
GO:0044822 [poly(A) RNA binding]
GO:2000623 [negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay]
Show all
 1143 aa
128.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.