Tissue expression of FADS2 - Summary - The Human Protein Atlas

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FADS2

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	FADS2
Gene description	Fatty acid desaturase 2
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA006741
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	FADS2 (HGNC Symbol)
Synonyms	D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13
Description	Fatty acid desaturase 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the fatty acid desaturase (FADS) gene family. Desaturase enzymes regulate unsaturation of fatty acids through the introduction of double bonds between defined carbons of the fatty acyl chain. FADS family members are considered fusion products composed of an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion, both of which are characterized by conserved histidine motifs. This gene is clustered with family members at 11q12-q13.1; this cluster is thought to have arisen evolutionarily from gene duplication based on its similar exon/intron organization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	61792980 - 61867354
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134824 (version 83.38)
Entrez gene	9415
UniProt	O95864 (UniProt - Evidence at protein level)
neXtProt	NX_O95864
Antibodypedia	FADS2 antibodies

PROTEIN BROWSER

FADS2-001	FADS2-002	FADS2-003	FADS2-004	FADS2-009	FADS2-010	FADS2-011	FADS2-012	FADS2-013	FADS2-014	FADS2-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FADS2-001 ENSP00000257261 ENST00000257261	O95864 [Direct mapping] Fatty acid desaturase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016213 [linoleoyl-CoA desaturase activity] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	422 aa 49.3 kDa	Yes	5
FADS2-002 ENSP00000429500 ENST00000522056	O95864 [Direct mapping] Fatty acid desaturase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016213 [linoleoyl-CoA desaturase activity] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	413 aa 48.9 kDa	No	5
FADS2-003 ENSP00000278840 ENST00000278840	O95864 [Direct mapping] Fatty acid desaturase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004768 [stearoyl-CoA 9-desaturase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016213 [linoleoyl-CoA desaturase activity] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	444 aa 52.3 kDa	No	5
FADS2-004 ENSP00000431091 ENST00000521849	O95864 [Direct mapping] Fatty acid desaturase 2 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0005887 [integral component of plasma membrane] GO:0006629 [lipid metabolic process] GO:0006636 [unsaturated fatty acid biosynthetic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016213 [linoleoyl-CoA desaturase activity] GO:0016491 [oxidoreductase activity] GO:0033559 [unsaturated fatty acid metabolic process] GO:0036109 [alpha-linolenic acid metabolic process] GO:0043651 [linoleic acid metabolic process] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] Show all	386 aa 45.5 kDa	No	5
FADS2-009 ENSP00000430225 ENST00000517312	E5RGD8 [Direct mapping] Fatty acid desaturase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] Show all	93 aa 10.8 kDa	No	1
FADS2-010 ENSP00000430054 ENST00000518606	E5RGZ5 [Direct mapping] Fatty acid desaturase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] Show all	103 aa 12.1 kDa	No	1
FADS2-011 ENSP00000429693 ENST00000517839	E5RHL3 [Direct mapping] Fatty acid desaturase 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		52 aa 6.1 kDa	No	0
FADS2-012 ENSP00000428522 ENST00000522639	F5GZU2 [Direct mapping] Fatty acid desaturase 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.9 kDa	No	0
FADS2-013 ENSP00000443867 ENST00000521571	F5GZ92 [Direct mapping] Fatty acid desaturase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	95 aa 11.6 kDa	No	2
FADS2-014 ENSP00000437965 ENST00000355484	F5H622 [Direct mapping] Fatty acid desaturase 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006629 [lipid metabolic process] GO:0016021 [integral component of membrane] Show all	151 aa 18.5 kDa	No	2
FADS2-015 ENSP00000458917 ENST00000574708	F5GZU2 [Direct mapping] Fatty acid desaturase 2 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		55 aa 5.9 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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