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CLOCK

GENERAL INFORMATION

Gene name

 CLOCK

Gene description

 Clock circadian regulator

Protein class

 Enzymes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA001867 , HPA027565
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA001867
HPA027565

GENE INFORMATION

Gene name

 CLOCK (HGNC Symbol)

Synonyms

 bHLHe8, KAT13D, KIAA0334

Description

 Clock circadian regulator (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 55427903 - 55547138

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134852 (version 83.38)

Entrez gene

 9575

UniProt

 O15516 (UniProt - Evidence at protein level)

neXtProt

 NX_O15516

Antibodypedia

 CLOCK antibodies

PROTEIN BROWSER
CLOCK-001
CLOCK-002
CLOCK-005
CLOCK-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLOCK-001
ENSP00000426983
ENST00000513440
O15516 [Direct mapping]
Circadian locomoter output cycles protein kaput
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0009648 [photoperiodism]
GO:0016573 [histone acetylation]
GO:0031490 [chromatin DNA binding]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051775 [response to redox state]
GO:0070888 [E-box binding]
GO:0071479 [cellular response to ionizing radiation]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
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 846 aa
95.3 kDa 		No 0
CLOCK-002
ENSP00000370723
ENST00000381322
O15516 [Direct mapping]
Circadian locomoter output cycles protein kaput
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001047 [core promoter binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005694 [chromosome]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0009648 [photoperiodism]
GO:0016573 [histone acetylation]
GO:0031490 [chromatin DNA binding]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050796 [regulation of insulin secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051775 [response to redox state]
GO:0070888 [E-box binding]
GO:0071479 [cellular response to ionizing radiation]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
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 846 aa
95.3 kDa 		No 0
CLOCK-005
ENSP00000308741
ENST00000309964
O15516 [Direct mapping]
Circadian locomoter output cycles protein kaput
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000077 [DNA damage checkpoint]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001046 [core promoter sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0004402 [histone acetyltransferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription factor complex]
GO:0005694 [chromosome]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007283 [spermatogenesis]
GO:0007623 [circadian rhythm]
GO:0009416 [response to light stimulus]
GO:0009648 [photoperiodism]
GO:0009649 [entrainment of circadian clock]
GO:0016573 [histone acetylation]
GO:0031490 [chromatin DNA binding]
GO:0032922 [circadian regulation of gene expression]
GO:0033391 [chromatoid body]
GO:0042634 [regulation of hair cycle]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0050729 [positive regulation of inflammatory response]
GO:0050796 [regulation of insulin secretion]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051775 [response to redox state]
GO:0070888 [E-box binding]
GO:0071479 [cellular response to ionizing radiation]
GO:2000074 [regulation of type B pancreatic cell development]
GO:2000323 [negative regulation of glucocorticoid receptor signaling pathway]
Show all
 846 aa
95.3 kDa 		No 0
CLOCK-010
ENSP00000396649
ENST00000435527
C9JK03 [Direct mapping]
Circadian locomoter output cycles protein kaput
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 182 aa
20.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.