Expression of COL4A2 in cancer - Summary

GENERAL INFORMATION
Gene name	COL4A2
Gene description	Collagen, type IV, alpha 2
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (EFO-21, WM-115)
HPA (normal tissue):	Tissue enhanced (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct membranous expression in various tissues, most prominent in smooth muscle, basal membranes, endothelium and connective tissue.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. CAB010751
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (unfavourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

CAB010751

GENE INFORMATION
Gene name	COL4A2 (HGNC Symbol)
Synonyms	DKFZp686I14213, FLJ22259
Description	Collagen, type IV, alpha 2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jul 2008]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	110305812 - 110513027
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134871 (version 83.38)
Entrez gene	1284
UniProt	P08572 (UniProt - Evidence at protein level)
neXtProt	NX_P08572
Antibodypedia	COL4A2 antibodies

PROTEIN BROWSER

COL4A2-001	COL4A2-004	COL4A2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COL4A2-001 ENSP00000353654 ENST00000360467	P08572 [Direct mapping] Collagen alpha-2(IV) chain Canstatin A0A024RDW8 [Target identity:100%; Query identity:100%] Collagen, type IV, alpha 2, isoform CRA_a Show all	SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005201 [extracellular matrix structural constituent] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0005587 [collagen type IV trimer] GO:0005604 [basement membrane] GO:0005788 [endoplasmic reticulum lumen] GO:0006351 [transcription, DNA-templated] GO:0006898 [receptor-mediated endocytosis] GO:0007411 [axon guidance] GO:0016525 [negative regulation of angiogenesis] GO:0022617 [extracellular matrix disassembly] GO:0030198 [extracellular matrix organization] GO:0030574 [collagen catabolic process] GO:0031012 [extracellular matrix] GO:0035987 [endodermal cell differentiation] GO:0043231 [intracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] GO:0071560 [cellular response to transforming growth factor beta stimulus] Show all	1712 aa 167.6 kDa	Yes	0
COL4A2-004 ENSP00000383027 ENST00000400163	A2A352 [Direct mapping] Collagen alpha-2(IV) chain Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 10.6 kDa	Yes	0
COL4A2-010 ENSP00000481492 ENST00000617564	A0A087WY39 [Direct mapping] Collagen alpha-2(IV) chain Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		42 aa 4.4 kDa	No	0