Expression of CLDN10 in cancer - Summary

GENERAL INFORMATION
Gene name	CLDN10
Gene description	Claudin 10
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (NTERA-2, RPTEC TERT1)
HPA (normal tissue):	Tissue enhanced (kidney)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in several tissues, most abundant in renal tubules, exocrine pancreas, gall bladder and salivary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA042348 , CAB012969
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and thyroid cancer (favourable).
Renal cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

STAINING SUMMARY

HPA042348	CAB012969

GENE INFORMATION
Gene name	CLDN10 (HGNC Symbol)
Synonyms	CPETRL3, OSP-L
Description	Claudin 10 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The expression level of this gene is associated with recurrence of primary hepatocellular carcinoma. Six alternatively spliced transcript variants encoding different isoforms have been reported, but the transcript sequences of some variants are not determined.[provided by RefSeq, Jun 2010]
Chromosome	13
Cytoband	q32.1
Chromosome location (bp)	95433604 - 95579759
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134873 (version 83.38)
Entrez gene	9071
UniProt	P78369 (UniProt - Evidence at transcript level)
neXtProt	NX_P78369
Antibodypedia	CLDN10 antibodies

PROTEIN BROWSER

CLDN10-001	CLDN10-002	CLDN10-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN10-001 ENSP00000366069 ENST00000376873	P78369 [Direct mapping] Claudin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006811 [ion transport] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] Show all	226 aa 24.3 kDa	No	3
CLDN10-002 ENSP00000299339 ENST00000299339	P78369 [Direct mapping] Claudin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0006811 [ion transport] GO:0007155 [cell adhesion] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] Show all	228 aa 24.5 kDa	No	3
CLDN10-003 ENSP00000366051 ENST00000376855	Q5W075 [Direct mapping] Claudin-10 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	73 aa 7.7 kDa	No	1