Expression of UBAC2 in cancer - Summary - The Human Protein Atlas

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UBAC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UBAC2
Gene description	UBA domain containing 2
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA013448
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013448

GENE INFORMATION
Gene name	UBAC2 (HGNC Symbol)
Synonyms	FLJ30548, PHGDHL1, RP11-178C10.1
Description	UBA domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q32.3
Chromosome location (bp)	99200774 - 99386434
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134882 (version 83.38)
Entrez gene	337867
UniProt	Q8NBM4 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NBM4
Antibodypedia	UBAC2 antibodies

PROTEIN BROWSER

UBAC2-001	UBAC2-002	UBAC2-007	UBAC2-008	UBAC2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UBAC2-001 ENSP00000365623 ENST00000376440	Q8NBM4 [Direct mapping] Ubiquitin-associated domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0070972 [protein localization to endoplasmic reticulum] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	309 aa 34.9 kDa	No	2
UBAC2-002 ENSP00000383911 ENST00000403766	Q8NBM4 [Direct mapping] Ubiquitin-associated domain-containing protein 2 A0A024RE02 [Target identity:100%; Query identity:100%] Phosphoglycerate dehydrogenase like 1, isoform CRA_c Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0070972 [protein localization to endoplasmic reticulum] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	344 aa 39 kDa	Yes	4
UBAC2-007 ENSP00000481260 ENST00000474510	A0A087WXT1 [Direct mapping] Ubiquitin-associated domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.9 kDa	No	0
UBAC2-008 ENSP00000347928 ENST00000355700	X6R5E5 [Direct mapping] Ubiquitin-associated domain-containing protein 2 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	204 aa 23.1 kDa	Yes	0
UBAC2-010 ENSP00000402249 ENST00000457666	Q5JUH4 [Direct mapping] Ubiquitin-associated domain-containing protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	135 aa 15.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.