Most of the cancer cells showed moderate cytoplasmic and/or nuclear immunoreactivity. Several ovarian cancers along with cases of urothelial, colorectal, pancreatic and stomach cancers were strongly stained. A majority of endometrial, testicular and renal cancers were weakly stained or negative.
Moderate to strong cytoplasmic and/or nuclear immunoreactivity was observed in most cancer cells. Most lymphomas, carcinoids, prostate, testicular and renal cancers were weakly stained or negative.
ERCC5 (HGNC Symbol)
Excision repair cross-complementation group 5 (HGNC Symbol)
Entrez gene summary
This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, mental retardation, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011]
P28715 [Direct mapping] DNA repair protein complementing XP-G cells
Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)