Expression of STT3A in cancer - Summary - The Human Protein Atlas

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STT3A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	STT3A
Gene description	STT3A, subunit of the oligosaccharyltransferase complex (catalytic)
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enriched (parathyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA030735
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable), liver cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001 Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030735

GENE INFORMATION
Gene name	STT3A (HGNC Symbol)
Synonyms	ITM1, MGC9042, STT3-A, TMC
Description	STT3A, subunit of the oligosaccharyltransferase complex (catalytic) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a catalytic subunit of the N-oligosaccharyltransferase (OST) complex, which functions in the endoplasmic reticulum to transfer glycan chains to asparagine residues of target proteins. A separate complex containing a similar catalytic subunit with an overlapping function also exists. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125591712 - 125625215
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134910 (version 83.38)
Entrez gene	3703
UniProt	P46977 (UniProt - Evidence at protein level)
neXtProt	NX_P46977
Antibodypedia	STT3A antibodies

PROTEIN BROWSER

STT3A-001	STT3A-002	STT3A-003	STT3A-005	STT3A-006	STT3A-007	STT3A-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
STT3A-001 ENSP00000376472 ENST00000392708	P46977 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Enzymes ENZYME proteins Transferases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043686 [co-translational protein modification] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	705 aa 80.5 kDa	No	>9
STT3A-002 ENSP00000436962 ENST00000529196	P46977 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Enzymes ENZYME proteins Transferases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043686 [co-translational protein modification] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	705 aa 80.5 kDa	No	>9
STT3A-003 ENSP00000432820 ENST00000531491	P46977 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Enzymes ENZYME proteins Transferases Transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0004579 [dolichyl-diphosphooligosaccharide-protein glycotransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006486 [protein glycosylation] GO:0008250 [oligosaccharyltransferase complex] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043686 [co-translational protein modification] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] Show all	613 aa 69.6 kDa	No	>9
STT3A-005 ENSP00000435810 ENST00000525652	A0A0C4DH80 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0006486 [protein glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	103 aa 12.2 kDa	No	2
STT3A-006 ENSP00000436558 ENST00000527606	E9PI32 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0006486 [protein glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	119 aa 14.1 kDa	No	2
STT3A-007 ENSP00000432912 ENST00000529886	E9PN73 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0006486 [protein glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	117 aa 13.9 kDa	No	2
STT3A-016 ENSP00000436523 ENST00000526726	H0YET6 [Direct mapping] Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004576 [oligosaccharyl transferase activity] GO:0006486 [protein glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	194 aa 21.4 kDa	No	4

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