Expression of ACRV1 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ACRV1

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACRV1
Gene description	Acrosomal vesicle protein 1
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective expression in acrosomes in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA038718 , HPA038719
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038718	HPA038719

GENE INFORMATION
Gene name	ACRV1 (HGNC Symbol)
Synonyms	D11S4365, SP-10, SPACA2
Description	Acrosomal vesicle protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2010]
Chromosome	11
Cytoband	q24.2
Chromosome location (bp)	125671522 - 125681123
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000134940 (version 83.38)
Entrez gene	56
UniProt	P26436 (UniProt - Evidence at protein level)
neXtProt	NX_P26436
Antibodypedia	ACRV1 antibodies

PROTEIN BROWSER

ACRV1-001	ACRV1-002	ACRV1-003	ACRV1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACRV1-001 ENSP00000432816 ENST00000533904	P26436 [Direct mapping] Acrosomal protein SP-10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0007275 [multicellular organismal development] Show all	265 aa 28.2 kDa	Yes	0
ACRV1-002 ENSP00000317684 ENST00000315608	P26436 [Direct mapping] Acrosomal protein SP-10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0007275 [multicellular organismal development] Show all	246 aa 26.4 kDa	Yes	0
ACRV1-003 ENSP00000436819 ENST00000527795	P26436 [Direct mapping] Acrosomal protein SP-10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0007275 [multicellular organismal development] Show all	195 aa 20.9 kDa	Yes	0
ACRV1-004 ENSP00000433720 ENST00000530048	P26436 [Direct mapping] Acrosomal protein SP-10 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0007275 [multicellular organismal development] Show all	210 aa 22.4 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.