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WDR36

GENERAL INFORMATION

Gene name

 WDR36

Gene description

 WD repeat domain 36

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic and nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA037796 , HPA037797
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PROGNOSTIC SUMMARY
Prognostic marker in thyroid cancer (unfavourable).
Thyroid cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037796
HPA037797

GENE INFORMATION

Gene name

 WDR36 (HGNC Symbol)

Synonyms

 GLC1G, TA-WDRP, UTP21

Description

 WD repeat domain 36 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Mutations in this gene have been associated with adult-onset primary open-angle glaucoma (POAG). [provided by RefSeq, Jul 2008]

Chromosome

 5

Cytoband

 q22.1

Chromosome location (bp)

 111091716 - 111130502

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000134987 (version 83.38)

Entrez gene

 134430

UniProt

 Q8NI36 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NI36

Antibodypedia

 WDR36 antibodies

PROTEIN BROWSER
WDR36-001
WDR36-010
WDR36-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
WDR36-001
ENSP00000423067
ENST00000506538
Q8NI36 [Direct mapping]
WD repeat-containing protein 36
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Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
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GO:0001895 [retina homeostasis]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0007601 [visual perception]
GO:0008150 [biological_process]
GO:0030516 [regulation of axon extension]
GO:0032040 [small-subunit processome]
GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome]
GO:0044822 [poly(A) RNA binding]
GO:0050896 [response to stimulus]
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 951 aa
105.3 kDa 		No 0
WDR36-010
ENSP00000424628
ENST00000513710
A0A0A0MTB8 [Direct mapping]
WD repeat-containing protein 36
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   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0006364 [rRNA processing]
GO:0032040 [small-subunit processome]
GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome]
Show all
 895 aa
99.4 kDa 		No 0
WDR36-201
ENSP00000479950
ENST00000612402
Q8NI36 [Direct mapping]
WD repeat-containing protein 36
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Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005730 [nucleolus]
GO:0006364 [rRNA processing]
GO:0007601 [visual perception]
GO:0008150 [biological_process]
GO:0032040 [small-subunit processome]
GO:0034388 [Pwp2p-containing subcomplex of 90S preribosome]
GO:0044822 [poly(A) RNA binding]
GO:0050896 [response to stimulus]
Show all
 951 aa
105.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.