Cell atlas - RFK - The Human Protein Atlas

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RFK

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Golgi apparatus

Human cell
	Golgi Apparatus

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GENERAL INFORMATION
Gene name	RFK
Gene description	Riboflavin kinase
Protein class	Enzymes FDA approved drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the Golgi apparatus.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Golgi apparatus (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA057163
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the Golgi apparatus.

Main location

Golgi apparatus (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA057163	A549	Golgi apparatus
	HPA057163	U-2 OS	Golgi apparatus
	HPA057163	U-251 MG	Golgi apparatus

GENE INFORMATION
Gene name	RFK (HGNC Symbol)
Synonyms	FLJ11149, RIFK
Description	Riboflavin kinase (HGNC Symbol)
Entrez gene summary	Riboflavin kinase (RFK; EC 2.7.1.26) is an essential enzyme that catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN), an obligatory step in vitamin B2 utilization and flavin cofactor synthesis (Karthikeyan et al., 2003 [PubMed 12623014]).[supplied by OMIM, Nov 2009]
Chromosome	9
Cytoband	q21.13
Chromosome location (bp)	76385517 - 76394517
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135002 (version 83.38)
Entrez gene	55312
UniProt	Q969G6 (UniProt - Evidence at protein level)
neXtProt	NX_Q969G6
Antibodypedia	RFK antibodies

PROTEIN BROWSER

RFK-001	RFK-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RFK-001 ENSP00000365926 ENST00000376736	Q969G6 [Direct mapping] Riboflavin kinase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0006766 [vitamin metabolic process] GO:0006767 [water-soluble vitamin metabolic process] GO:0006771 [riboflavin metabolic process] GO:0006915 [apoptotic process] GO:0008531 [riboflavin kinase activity] GO:0009231 [riboflavin biosynthetic process] GO:0009398 [FMN biosynthetic process] GO:0016310 [phosphorylation] GO:0033864 [positive regulation of NAD(P)H oxidase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0072593 [reactive oxygen species metabolic process] Show all	155 aa 17.6 kDa	No	0
RFK-004 ENSP00000417215 ENST00000490113	H7C4G0 [Direct mapping] Riboflavin kinase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008531 [riboflavin kinase activity] GO:0009231 [riboflavin biosynthetic process] GO:0016310 [phosphorylation] Show all	120 aa 13.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.