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CTSL

GENERAL INFORMATION

Gene name

 CTSL

Gene description

 Cathepsin L

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (ASC TERT1)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 lysosomal expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
CAB000459
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable), renal cancer (favourable) and glioma (unfavourable).
Lung cancer p<0.001
Renal cancer p<0.001
Glioma p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB000459

GENE INFORMATION

Gene name

 CTSL (HGNC Symbol)

Synonyms

 CTSL1, FLJ31037

Description

 Cathepsin L (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]

Chromosome

 9

Cytoband

 q21.33

Chromosome location (bp)

 87725519 - 87731393

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135047 (version 83.38)

Entrez gene

 1514

UniProt

 P07711 (UniProt - Evidence at protein level)

neXtProt

 NX_P07711

Antibodypedia

 CTSL antibodies

PROTEIN BROWSER
CTSL-001
CTSL-002
CTSL-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTSL-001
ENSP00000345344
ENST00000343150
P07711 [Direct mapping]
Cathepsin L1 Cathepsin L1 heavy chain Cathepsin L1 light chain
A0A024R276 [Target identity:100%; Query identity:100%]
Cathepsin L, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0036021 [endolysosome lumen]
GO:0042393 [histone binding]
GO:0043202 [lysosomal lumen]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071888 [macrophage apoptotic process]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:0097655 [serpin family protein binding]
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 333 aa
37.6 kDa 		Yes 0
CTSL-002
ENSP00000365061
ENST00000340342
P07711 [Direct mapping]
Cathepsin L1 Cathepsin L1 heavy chain Cathepsin L1 light chain
A0A024R276 [Target identity:100%; Query identity:100%]
Cathepsin L, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001968 [fibronectin binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002250 [adaptive immune response]
GO:0004197 [cysteine-type endopeptidase activity]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005764 [lysosome]
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
GO:0019882 [antigen processing and presentation]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0030574 [collagen catabolic process]
GO:0036021 [endolysosome lumen]
GO:0042393 [histone binding]
GO:0043202 [lysosomal lumen]
GO:0043394 [proteoglycan binding]
GO:0045087 [innate immune response]
GO:0051603 [proteolysis involved in cellular protein catabolic process]
GO:0070062 [extracellular exosome]
GO:0071888 [macrophage apoptotic process]
GO:0097067 [cellular response to thyroid hormone stimulus]
GO:0097655 [serpin family protein binding]
Show all
 333 aa
37.6 kDa 		Yes 0
CTSL-004
ENSP00000340470
ENST00000342020
Q5T8F0 [Direct mapping]
Cathepsin L1
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   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0006508 [proteolysis]
GO:0008234 [cysteine-type peptidase activity]
Show all
 225 aa
25.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.