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AGTPBP1

GENERAL INFORMATION

Gene name

 AGTPBP1

Gene description

 ATP/GTP binding protein 1

Protein class

 Enzymes
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA057208
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057208

GENE INFORMATION

Gene name

 AGTPBP1 (HGNC Symbol)

Synonyms

 CCP1, KIAA1035, Nna1

Description

 ATP/GTP binding protein 1 (HGNC Symbol)

Entrez gene summary

 NNA1 is a zinc carboxypeptidase that contains nuclear localization signals and an ATP/GTP-binding motif that was initially cloned from regenerating spinal cord neurons of the mouse.[supplied by OMIM, Jul 2002]

Chromosome

 9

Cytoband

 q21.33

Chromosome location (bp)

 85546539 - 85742029

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135049 (version 83.38)

Entrez gene

 23287

UniProt

 Q9UPW5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPW5

Antibodypedia

 AGTPBP1 antibodies

PROTEIN BROWSER
AGTPBP1-004
AGTPBP1-005
AGTPBP1-007
AGTPBP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AGTPBP1-004
ENSP00000349592
ENST00000357081
Q9UPW5 [Direct mapping]
Cytosolic carboxypeptidase 1
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001754 [eye photoreceptor cell differentiation]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0015631 [tubulin binding]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021772 [olfactory bulb development]
GO:0035609 [C-terminal protein deglutamylation]
GO:0035610 [protein side chain deglutamylation]
GO:0050905 [neuromuscular process]
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 1226 aa
138.4 kDa 		No 0
AGTPBP1-005
ENSP00000365251
ENST00000376083
Q9UPW5 [Direct mapping]
Cytosolic carboxypeptidase 1
A0A024R288 [Target identity:100%; Query identity:100%]
ATP/GTP binding protein 1, isoform CRA_a
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Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001754 [eye photoreceptor cell differentiation]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0015631 [tubulin binding]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021772 [olfactory bulb development]
GO:0035609 [C-terminal protein deglutamylation]
GO:0035610 [protein side chain deglutamylation]
GO:0050905 [neuromuscular process]
Show all
 1186 aa
133.9 kDa 		No 0
AGTPBP1-007
ENSP00000487074
ENST00000628899
Q9UPW5 [Direct mapping]
Cytosolic carboxypeptidase 1
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Enzymes
   Peptidases
   Metallopeptidases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001754 [eye photoreceptor cell differentiation]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005488 [binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0007005 [mitochondrion organization]
GO:0008270 [zinc ion binding]
GO:0015631 [tubulin binding]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021772 [olfactory bulb development]
GO:0035609 [C-terminal protein deglutamylation]
GO:0035610 [protein side chain deglutamylation]
GO:0050905 [neuromuscular process]
Show all
 1238 aa
138.6 kDa 		Yes 0
AGTPBP1-201
ENSP00000338512
ENST00000337006
J3KNS1 [Direct mapping]
Cytosolic carboxypeptidase 1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001754 [eye photoreceptor cell differentiation]
GO:0004181 [metallocarboxypeptidase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0007005 [mitochondrion organization]
GO:0007628 [adult walking behavior]
GO:0008270 [zinc ion binding]
GO:0015631 [tubulin binding]
GO:0021549 [cerebellum development]
GO:0021680 [cerebellar Purkinje cell layer development]
GO:0021702 [cerebellar Purkinje cell differentiation]
GO:0021772 [olfactory bulb development]
GO:0035609 [C-terminal protein deglutamylation]
GO:0035610 [protein side chain deglutamylation]
GO:0042133 [neurotransmitter metabolic process]
GO:0050905 [neuromuscular process]
GO:0060041 [retina development in camera-type eye]
Show all
 1278 aa
143.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.