Expression of ADAM19 in cancer - Summary - The Human Protein Atlas

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ADAM19

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ADAM19
Gene description	ADAM metallopeptidase domain 19
Protein class	Enzymes Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, U-251 MG)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ADAM19 (HGNC Symbol)
Synonyms	MLTNB
Description	ADAM metallopeptidase domain 19 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013]
Chromosome	5
Cytoband	q33.3
Chromosome location (bp)	157395534 - 157575775
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135074 (version 83.38)
Entrez gene	8728
UniProt	Q9H013 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H013
Antibodypedia	ADAM19 antibodies

PROTEIN BROWSER

ADAM19-001	ADAM19-003	ADAM19-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADAM19-001 ENSP00000257527 ENST00000257527	Q9H013 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 19 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0005794 [Golgi apparatus] GO:0006508 [proteolysis] GO:0006509 [membrane protein ectodomain proteolysis] GO:0007507 [heart development] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] Show all	918 aa 100.8 kDa	Yes	1
ADAM19-003 ENSP00000428654 ENST00000517905	Q9H013 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 19 Show all	Enzymes Peptidases Metallopeptidases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0008270 [zinc ion binding] GO:0016021 [integral component of membrane] GO:0017124 [SH3 domain binding] Show all	955 aa 105 kDa	Yes	1
ADAM19-004 ENSP00000431027 ENST00000517374	H0YC66 [Direct mapping] Disintegrin and metalloproteinase domain-containing protein 19 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004222 [metalloendopeptidase activity] GO:0005515 [protein binding] GO:0006508 [proteolysis] GO:0016021 [integral component of membrane] Show all	489 aa 52.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.