Fields »
ABOUT
HELP
BLOG
HAVCR2

GENERAL INFORMATION

Gene name

 HAVCR2

Gene description

 Hepatitis A virus cellular receptor 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of lymphoid cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
CAB026003
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 HAVCR2 (HGNC Symbol)

Synonyms

 CD366, FLJ14428, Tim-3, TIM3, TIMD3

Description

 Hepatitis A virus cellular receptor 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]

Chromosome

 5

Cytoband

 q33.3

Chromosome location (bp)

 157085832 - 157142869

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135077 (version 83.38)

Entrez gene

 84868

UniProt

 Q8TDQ0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TDQ0

Antibodypedia

 HAVCR2 antibodies

PROTEIN BROWSER
HAVCR2-001
HAVCR2-004
HAVCR2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HAVCR2-001
ENSP00000312002
ENST00000307851
Q8TDQ0 [Direct mapping]
Hepatitis A virus cellular receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001819 [positive regulation of cytokine production]
GO:0002519 [natural killer cell tolerance induction]
GO:0005515 [protein binding]
GO:0009986 [cell surface]
GO:0010629 [negative regulation of gene expression]
GO:0016021 [integral component of membrane]
GO:0032720 [negative regulation of tumor necrosis factor production]
GO:0032722 [positive regulation of chemokine production]
GO:0032732 [positive regulation of interleukin-1 production]
GO:0032753 [positive regulation of interleukin-4 production]
GO:0043032 [positive regulation of macrophage activation]
GO:0045089 [positive regulation of innate immune response]
GO:0060135 [maternal process involved in female pregnancy]
GO:0070062 [extracellular exosome]
GO:1900426 [positive regulation of defense response to bacterium]
Show all
 301 aa
33.4 kDa 		Yes 1
HAVCR2-004
ENSP00000430873
ENST00000522593
E5RHN3 [Direct mapping]
Hepatitis A virus cellular receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0016021 [integral component of membrane]
Show all
 273 aa
30.3 kDa 		Yes 1
HAVCR2-007
ENSP00000430328
ENST00000524219
E5RFR4 [Direct mapping]
Hepatitis A virus cellular receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 74 aa
8.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.