Cell atlas - SDS - The Human Protein Atlas

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SDS

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Mitochondria

Human cell
	Cytosol
	Mitochondria

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GENERAL INFORMATION
Gene name	SDS
Gene description	Serine dehydratase
Protein class	Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the mitochondria.
RNA cell category	Cell line enhanced (HMC-1)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)
Additional location	In addition localized to the Mitochondria (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA039230
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HMC-1) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the mitochondria.

Main location

Cytosol (approved)

Additional location

Mitochondria (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA039230	A-431	Cytosol
	HPA039230	U-2 OS	Mitochondria
	HPA039230	U-2 OS	Cytosol
	HPA039230	U-251 MG	Cytosol

GENE INFORMATION
Gene name	SDS (HGNC Symbol)
Synonyms	SDH
Description	Serine dehydratase (HGNC Symbol)
Entrez gene summary	This gene encodes one of three enzymes that are involved in metabolizing serine and glycine. L-serine dehydratase converts L-serine to pyruvate and ammonia and requires pyridoxal phosphate as a cofactor. The encoded protein can also metabolize threonine to NH4+ and 2-ketobutyrate. The encoded protein is found predominantly in the liver. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.13
Chromosome location (bp)	113392445 - 113426301
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135094 (version 83.38)
Entrez gene	10993
UniProt	P20132 (UniProt - Evidence at protein level)
neXtProt	NX_P20132
Antibodypedia	SDS antibodies

PROTEIN BROWSER

SDS-001	SDS-005	SDS-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SDS-001 ENSP00000257549 ENST00000257549	P20132 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Enzymes ENZYME proteins Lyases MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0003941 [L-serine ammonia-lyase activity] GO:0004794 [L-threonine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006094 [gluconeogenesis] GO:0006520 [cellular amino acid metabolic process] GO:0006565 [L-serine catabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] GO:0042803 [protein homodimerization activity] GO:0042866 [pyruvate biosynthetic process] Show all	328 aa 34.6 kDa	No	0
SDS-005 ENSP00000449833 ENST00000552280	F8VW93 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Predicted intracellular proteins Show all	GO:0004794 [L-threonine ammonia-lyase activity] GO:0006520 [cellular amino acid metabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	97 aa 10.1 kDa	No	0
SDS-006 ENSP00000449061 ENST00000547342	F8VXS0 [Direct mapping] L-serine dehydratase/L-threonine deaminase Show all	Predicted intracellular proteins Show all	GO:0004794 [L-threonine ammonia-lyase activity] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0006520 [cellular amino acid metabolic process] GO:0006567 [threonine catabolic process] GO:0030170 [pyridoxal phosphate binding] Show all	235 aa 25.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.