Cell atlas - MSI1 - The Human Protein Atlas

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MSI1

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Vesicles

Human cell
	Cytosol
	Nucleoplasm
	Vesicles

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GENERAL INFORMATION
Gene name	MSI1
Gene description	Musashi RNA-binding protein 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.
RNA cell category	Cell line enhanced (AF22, SCLC-21H, NTERA-2, SH-SY5Y)
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved), Cytosol (approved)
Additional location	In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA064401
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (AF22, SCLC-21H, NTERA-2, SH-SY5Y) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol & vesicles. In addition localized to the nucleoplasm.

Main location

Vesicles (approved), Cytosol (approved)

Additional location

Nucleoplasm (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA064401	CACO-2	Nucleoplasm
			Vesicles
			Cytosol
	HPA064401	SH-SY5Y	Nucleoplasm
			Vesicles
			Cytosol
	HPA064401	U-2 OS	Nucleoplasm
			Vesicles
			Cytosol

GENE INFORMATION
Gene name	MSI1
Synonyms
Description	Musashi RNA-binding protein 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Expression of this gene has been correlated with the grade of the malignancy and proliferative activity in gliomas and melanomas. A pseudogene for this gene is located on chromosome 11q13. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120341330 - 120369180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135097 (version 83.38)
Entrez gene	4440
UniProt	O43347 (UniProt - Evidence at protein level)
neXtProt	NX_O43347
Antibodypedia	MSI1 antibodies

PROTEIN BROWSER

MSI1-001	MSI1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MSI1-001 ENSP00000257552 ENST00000257552	O43347 [Direct mapping] RNA-binding protein Musashi homolog 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003727 [single-stranded RNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005844 [polysome] GO:0007399 [nervous system development] GO:0008266 [poly(U) RNA binding] GO:0044822 [poly(A) RNA binding] Show all	362 aa 39.1 kDa	No	0
MSI1-002 ENSP00000446710 ENST00000546985	H0YHB7 [Direct mapping] RNA-binding protein Musashi homolog 1 Show all	TMHMM predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0003676 [nucleic acid binding] Show all	233 aa 25.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.