Expression of HRK in cancer - Summary - The Human Protein Atlas

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HRK

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HRK
Gene description	Harakiri, BCL2 interacting protein
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (SCLC-21H, SH-SY5Y, SK-MEL-30, U-698)
HPA (normal tissue):	Group enriched (cerebral cortex, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. CAB025973
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB025973

GENE INFORMATION
Gene name	HRK (HGNC Symbol)
Synonyms	DP5
Description	Harakiri, BCL2 interacting protein (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the BCL-2 protein family. Members of this family are involved in activating or inhibiting apoptosis. The encoded protein localizes to intracellular membranes. This protein promotes apoptosis by interacting with the apoptotic inhibitors BCL-2 and BCL-X(L) via its BH3 domain. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2012]
Chromosome	12
Cytoband	q24.22
Chromosome location (bp)	116856144 - 116881441
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135116 (version 83.38)
Entrez gene	8739
UniProt	O00198 (UniProt - Evidence at protein level)
neXtProt	NX_O00198
Antibodypedia	HRK antibodies

PROTEIN BROWSER

HRK-001	HRK-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HRK-001 ENSP00000257572 ENST00000257572	O00198 [Direct mapping] Activator of apoptosis harakiri Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] GO:0032464 [positive regulation of protein homooligomerization] GO:0042981 [regulation of apoptotic process] GO:0043065 [positive regulation of apoptotic process] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] Show all	91 aa 9.9 kDa	No	1
HRK-002 ENSP00000465379 ENST00000550505	K7EJY7 [Direct mapping] Activator of apoptosis harakiri Show all	Predicted intracellular proteins Show all		18 aa 1.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.