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DTX1

GENERAL INFORMATION

Gene name

 DTX1

Gene description

 Deltex 1, E3 ubiquitin ligase

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues, including lymphoid organs and CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA055275
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 DTX1 (HGNC Symbol)

Synonyms

 hDx-1

Description

 Deltex 1, E3 ubiquitin ligase (HGNC Symbol)

Entrez gene summary

 Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 113056709 - 113098028

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135144 (version 83.38)

Entrez gene

 1840

UniProt

 Q86Y01 (UniProt - Evidence at protein level)

neXtProt

 NX_Q86Y01

Antibodypedia

 DTX1 antibodies

PROTEIN BROWSER
DTX1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DTX1-001
ENSP00000257600
ENST00000257600
Q86Y01 [Direct mapping]
E3 ubiquitin-protein ligase DTX1
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   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003713 [transcription coactivator activity]
GO:0005112 [Notch binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0008270 [zinc ion binding]
GO:0008593 [regulation of Notch signaling pathway]
GO:0010001 [glial cell differentiation]
GO:0016567 [protein ubiquitination]
GO:0016874 [ligase activity]
GO:0017124 [SH3 domain binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0045581 [negative regulation of T cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:1903506 [regulation of nucleic acid-templated transcription]
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 620 aa
67.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.