Expression of TMEM60 in cancer - Summary - The Human Protein Atlas

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TMEM60

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TMEM60
Gene description	Transmembrane protein 60
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues, mainly in GI.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA062625
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable) and glioma (unfavourable).
Breast cancer p<0.001 Glioma p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA062625

GENE INFORMATION
Gene name	TMEM60 (HGNC Symbol)
Synonyms	C7orf35, DC32
Description	Transmembrane protein 60 (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q11.23
Chromosome location (bp)	77793728 - 77798580
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000135211 (version 83.38)
Entrez gene	85025
UniProt	Q9H2L4 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9H2L4
Antibodypedia	TMEM60 antibodies

PROTEIN BROWSER

TMEM60-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TMEM60-001 ENSP00000257663 ENST00000257663	Q9H2L4 [Direct mapping] Transmembrane protein 60 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	133 aa 15.5 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.