Expression of HILPDA in cancer - Summary - The Human Protein Atlas

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HILPDA

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HILPDA
Gene description	Hypoxia inducible lipid droplet-associated
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA010515
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010515

GENE INFORMATION
Gene name	HILPDA (HGNC Symbol)
Synonyms	C7orf68, FLJ21076, HIG-2, HIG2
Description	Hypoxia inducible lipid droplet-associated (HGNC Symbol)
Entrez gene summary
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128455849 - 128458418
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135245 (version 83.38)
Entrez gene	29923
UniProt	Q9Y5L2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y5L2
Antibodypedia	HILPDA antibodies

PROTEIN BROWSER

HILPDA-001	HILPDA-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HILPDA-001 ENSP00000257696 ENST00000257696	Q9Y5L2 [Direct mapping] Hypoxia-inducible lipid droplet-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0002230 [positive regulation of defense response to virus by host] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005811 [lipid particle] GO:0006950 [response to stress] GO:0008284 [positive regulation of cell proliferation] GO:0009986 [cell surface] GO:0010884 [positive regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0030141 [secretory granule] GO:0035425 [autocrine signaling] Show all	63 aa 7 kDa	No	1
HILPDA-005 ENSP00000388871 ENST00000435296	Q9Y5L2 [Direct mapping] Hypoxia-inducible lipid droplet-associated protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0001819 [positive regulation of cytokine production] GO:0002230 [positive regulation of defense response to virus by host] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005811 [lipid particle] GO:0006950 [response to stress] GO:0008284 [positive regulation of cell proliferation] GO:0009986 [cell surface] GO:0010884 [positive regulation of lipid storage] GO:0016021 [integral component of membrane] GO:0030141 [secretory granule] GO:0035425 [autocrine signaling] Show all	63 aa 7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.