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SRPK2

GENERAL INFORMATION

Gene name

 SRPK2

Gene description

 SRSF protein kinase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Group enriched (cerebral cortex, testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in selected cell types, most abundant in cells in seminiferous ducts and neuronal cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA015522 , HPA020876
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA015522
HPA020876

GENE INFORMATION

Gene name

 SRPK2 (HGNC Symbol)

Synonyms

 SFRSK2

Description

 SRSF protein kinase 2 (HGNC Symbol)

Entrez gene summary

Chromosome

 7

Cytoband

 q22.3

Chromosome location (bp)

 105110704 - 105399308

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135250 (version 83.38)

Entrez gene

 6733

UniProt

 P78362 (UniProt - Evidence at protein level)

neXtProt

 NX_P78362

Antibodypedia

 SRPK2 antibodies

PROTEIN BROWSER
SRPK2-001
SRPK2-002
SRPK2-006
SRPK2-007
SRPK2-008
SRPK2-013
SRPK2-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SRPK2-001
ENSP00000349863
ENST00000357311
P78362 [Direct mapping]
SRSF protein kinase 2 SRSF protein kinase 2 N-terminal SRSF protein kinase 2 C-terminal
A0A024R704 [Target identity:100%; Query identity:100%]
SFRS protein kinase 2, isoform CRA_b
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0035063 [nuclear speck organization]
GO:0035556 [intracellular signal transduction]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045787 [positive regulation of cell cycle]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0071889 [14-3-3 protein binding]
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 688 aa
77.5 kDa 		No 0
SRPK2-002
ENSP00000419791
ENST00000489828
P78362 [Direct mapping]
SRSF protein kinase 2 SRSF protein kinase 2 N-terminal SRSF protein kinase 2 C-terminal
A0A024R704 [Target identity:100%; Query identity:100%]
SFRS protein kinase 2, isoform CRA_b
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0035063 [nuclear speck organization]
GO:0035556 [intracellular signal transduction]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045787 [positive regulation of cell cycle]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0071889 [14-3-3 protein binding]
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 688 aa
77.5 kDa 		No 0
SRPK2-006
ENSP00000418786
ENST00000474770
H7C521 [Direct mapping]
SRSF protein kinase 2
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   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 204 aa
23.5 kDa 		No 0
SRPK2-007
ENSP00000420208
ENST00000477925
H7C5L6 [Direct mapping]
SRSF protein kinase 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 295 aa
33.2 kDa 		No 0
SRPK2-008
ENSP00000377262
ENST00000393651
P78362 [Direct mapping]
SRSF protein kinase 2 SRSF protein kinase 2 N-terminal SRSF protein kinase 2 C-terminal
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   CMGC Ser/Thr protein kinases
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000245 [spliceosomal complex assembly]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006468 [protein phosphorylation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008380 [RNA splicing]
GO:0010628 [positive regulation of gene expression]
GO:0030154 [cell differentiation]
GO:0035063 [nuclear speck organization]
GO:0035556 [intracellular signal transduction]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0044822 [poly(A) RNA binding]
GO:0045070 [positive regulation of viral genome replication]
GO:0045071 [negative regulation of viral genome replication]
GO:0045087 [innate immune response]
GO:0045787 [positive regulation of cell cycle]
GO:0048024 [regulation of mRNA splicing, via spliceosome]
GO:0071889 [14-3-3 protein binding]
Show all
 699 aa
79 kDa 		No 0
SRPK2-013
ENSP00000417357
ENST00000460391
C9J2M4 [Direct mapping]
SRSF protein kinase 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 160 aa
17.9 kDa 		No 0
SRPK2-014
ENSP00000419240
ENST00000482897
C9JWF7 [Direct mapping]
SRSF protein kinase 2
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004672 [protein kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
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 231 aa
25.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.