Expression of ADGRB3 in cancer - Summary - The Human Protein Atlas

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ADGRB3

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	ADGRB3
Gene description	Adhesion G protein-coupled receptor B3
Protein class	G-protein coupled receptors Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (glioma)
HPA (cell line):	Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (glioma)

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	ADGRB3 (HGNC Symbol)
Synonyms	BAI3, KIAA0550
Description	Adhesion G protein-coupled receptor B3 (HGNC Symbol)
Entrez gene summary	This p53-target gene encodes a brain-specific angiogenesis inhibitor, a seven-span transmembrane protein, and is thought to be a member of the secretin receptor family. Brain-specific angiogenesis proteins BAI2 and BAI3 are similar to BAI1 in structure, have similar tissue specificities, and may also play a role in angiogenesis. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband
Chromosome location (bp)	68635367 - 69389511
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135298 (version 83.38)
Entrez gene	577
UniProt	O60242 (UniProt - Evidence at protein level)
neXtProt	NX_O60242
Antibodypedia	ADGRB3 antibodies

PROTEIN BROWSER

ADGRB3-001	ADGRB3-002	ADGRB3-003	ADGRB3-004	ADGRB3-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADGRB3-001 ENSP00000359630 ENST00000370598	O60242 [Direct mapping] Adhesion G protein-coupled receptor B3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007520 [myoblast fusion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0043547 [positive regulation of GTPase activity] GO:0048814 [regulation of dendrite morphogenesis] GO:0051965 [positive regulation of synapse assembly] Show all	1522 aa 171.5 kDa	No	7
ADGRB3-002 ENSP00000238918 ENST00000238918	J3KMY8 [Direct mapping] Protein ADGRB3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] Show all	728 aa 81.7 kDa	No	7
ADGRB3-003 ENSP00000474165 ENST00000604969	S4R3D0 [Direct mapping] Protein ADGRB3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	68 aa 7.4 kDa	No	2
ADGRB3-004 ENSP00000473827 ENST00000603207	S4R307 [Direct mapping] Protein ADGRB3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	145 aa 16.1 kDa	No	3
ADGRB3-201 ENSP00000441821 ENST00000546190	O60242 [Direct mapping] Adhesion G protein-coupled receptor B3 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Family 2 (B) receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Plasma proteins Show all	GO:0004888 [transmembrane signaling receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007166 [cell surface receptor signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007520 [myoblast fusion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016525 [negative regulation of angiogenesis] GO:0048814 [regulation of dendrite morphogenesis] Show all	1522 aa 171.5 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.