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HTR1B

GENERAL INFORMATION

Gene name

 HTR1B

Gene description

 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

Protein class

 FDA approved drug targets
G-protein coupled receptors
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (HUVEC TERT2, TIME)
HPA (normal tissue):Tissue enhanced (placenta, stomach)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in endothelial cells

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA028808
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA028808

GENE INFORMATION

Gene name

 HTR1B (HGNC Symbol)

Synonyms

 5-HT1B, 5-HT1DB, HTR1D2, S12

Description

 5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled (HGNC Symbol)

Entrez gene summary

 The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of adenylate cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

Chromosome

 6

Cytoband

 q14.1

Chromosome location (bp)

 77462205 - 77463464

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135312 (version 83.38)

Entrez gene

 3351

UniProt

 P28222 (UniProt - Evidence at protein level)

neXtProt

 NX_P28222

Antibodypedia

 HTR1B antibodies

PROTEIN BROWSER
HTR1B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HTR1B-001
ENSP00000358963
ENST00000369947
P28222 [Direct mapping]
5-hydroxytryptamine receptor 1B
X5D7I5 [Target identity:100%; Query identity:100%]
5-hydroxytryptamine (Serotonin) receptor 1B; G protein-coupled 5-hydroxytryptamine serotonin receptor 1B isoform A
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Transporters
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Serotonin receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
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GO:0002031 [G-protein coupled receptor internalization]
GO:0004930 [G-protein coupled receptor activity]
GO:0004993 [serotonin receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007187 [G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger]
GO:0007198 [adenylate cyclase-inhibiting serotonin receptor signaling pathway]
GO:0007205 [protein kinase C-activating G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007631 [feeding behavior]
GO:0008144 [drug binding]
GO:0014059 [regulation of dopamine secretion]
GO:0014063 [negative regulation of serotonin secretion]
GO:0016021 [integral component of membrane]
GO:0030818 [negative regulation of cAMP biosynthetic process]
GO:0032229 [negative regulation of synaptic transmission, GABAergic]
GO:0035690 [cellular response to drug]
GO:0042220 [response to cocaine]
GO:0042310 [vasoconstriction]
GO:0042493 [response to drug]
GO:0042756 [drinking behavior]
GO:0045471 [response to ethanol]
GO:0046849 [bone remodeling]
GO:0050795 [regulation of behavior]
GO:0051378 [serotonin binding]
GO:0051385 [response to mineralocorticoid]
GO:0051967 [negative regulation of synaptic transmission, glutamatergic]
GO:0071312 [cellular response to alkaloid]
GO:0071502 [cellular response to temperature stimulus]
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 390 aa
43.6 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.