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Most cancers showed weak to moderate cytoplasmic positivity. Several lymphoma, renal and pancreatic cancers were negative.
GENE INFORMATION
Gene name
SNX14 (HGNC Symbol)
Synonyms
RGS-PX2
Description
Sorting nexin 14 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]