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ORC3

GENERAL INFORMATION

Gene name

 ORC3

Gene description

 Origin recognition complex, subunit 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA053748
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (unfavourable) and renal cancer (unfavourable).
Endometrial cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA053748

GENE INFORMATION

Gene name

 ORC3 (HGNC Symbol)

Synonyms

 IMAGE50150, LATHEO, ORC3L

Description

 Origin recognition complex, subunit 3 (HGNC Symbol)

Entrez gene summary

 The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Studies of a similar gene in Drosophila suggested a possible role of this protein in neuronal proliferation and olfactory memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q15

Chromosome location (bp)

 87590067 - 87667453

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135336 (version 83.38)

Entrez gene

 23595

UniProt

 Q9UBD5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBD5

Antibodypedia

 ORC3 antibodies

PROTEIN BROWSER
ORC3-001
ORC3-004
ORC3-005
ORC3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ORC3-001
ENSP00000376586
ENST00000392844
Q9UBD5 [Direct mapping]
Origin recognition complex subunit 3
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   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
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 711 aa
82.3 kDa 		No 0
ORC3-004
ENSP00000257789
ENST00000257789
Q9UBD5 [Direct mapping]
Origin recognition complex subunit 3
Show all
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
GO:0061351 [neural precursor cell proliferation]
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 712 aa
82.3 kDa 		No 0
ORC3-005
ENSP00000475988
ENST00000508875
U3KQL3 [Direct mapping]
Origin recognition complex subunit 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 32 aa
3.7 kDa 		No 0
ORC3-201
ENSP00000444695
ENST00000546266
Q9UBD5 [Direct mapping]
Origin recognition complex subunit 3
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   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0000784 [nuclear chromosome, telomeric region]
GO:0000808 [origin recognition complex]
GO:0003677 [DNA binding]
GO:0003688 [DNA replication origin binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005664 [nuclear origin of replication recognition complex]
GO:0006260 [DNA replication]
Show all
 568 aa
65.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.