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MAP3K7

GENERAL INFORMATION

Gene name

 MAP3K7

Gene description

 Mitogen-activated protein kinase kinase kinase 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA007633
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA007633

GENE INFORMATION

Gene name

 MAP3K7 (HGNC Symbol)

Synonyms

 MEKK7, TAK1

Description

 Mitogen-activated protein kinase kinase kinase 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q15

Chromosome location (bp)

 90513573 - 90587045

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135341 (version 83.38)

Entrez gene

 6885

UniProt

 O43318 (UniProt - Evidence at protein level)

neXtProt

 NX_O43318

Antibodypedia

 MAP3K7 antibodies

PROTEIN BROWSER
MAP3K7-001
MAP3K7-002
MAP3K7-003
MAP3K7-004
MAP3K7-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP3K7-001
ENSP00000358338
ENST00000369332
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 579 aa
64.2 kDa 		No 0
MAP3K7-002
ENSP00000358335
ENST00000369329
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0001525 [angiogenesis]
GO:0001841 [neural tube formation]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004708 [MAP kinase kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007165 [signal transduction]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0046330 [positive regulation of JNK cascade]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
GO:0097481 [neuronal postsynaptic density]
GO:1902443 [negative regulation of ripoptosome assembly involved in necroptotic process]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2001234 [negative regulation of apoptotic signaling pathway]
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 606 aa
67.2 kDa 		No 0
MAP3K7-003
ENSP00000358331
ENST00000369325
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 518 aa
56.7 kDa 		No 0
MAP3K7-004
ENSP00000358333
ENST00000369327
O43318 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   STE Ser/Thr protein kinases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000186 [activation of MAPKK activity]
GO:0000187 [activation of MAPK activity]
GO:0000287 [magnesium ion binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004709 [MAP kinase kinase kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005671 [Ada2/Gcn5/Ada3 transcription activator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006351 [transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0006915 [apoptotic process]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0007252 [I-kappaB phosphorylation]
GO:0007254 [JNK cascade]
GO:0008385 [IkappaB kinase complex]
GO:0010008 [endosome membrane]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0035872 [nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043966 [histone H3 acetylation]
GO:0045087 [innate immune response]
GO:0050852 [T cell receptor signaling pathway]
GO:0050870 [positive regulation of T cell activation]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051403 [stress-activated MAPK cascade]
GO:0070423 [nucleotide-binding oligomerization domain containing signaling pathway]
GO:0097110 [scaffold protein binding]
Show all
 491 aa
53.7 kDa 		No 0
MAP3K7-006
ENSP00000358326
ENST00000369320
Q9UG54 [Direct mapping]
Mitogen-activated protein kinase kinase kinase 7; Putative uncharacterized protein DKFZp586F0420
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 260 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.