Expression of CGA in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CGA
Gene description	Glycoprotein hormones, alpha polypeptide
Protein class	Cancer-related genes Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Tissue enriched (placenta)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in placental syncytiotrophoblasts and in pituitary gland.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA029698 , CAB023350
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA029698	CAB023350

GENE INFORMATION
Gene name	CGA (HGNC Symbol)
Synonyms	FSHA, GPHa, GPHA1, HCG, LHA, TSHA
Description	Glycoprotein hormones, alpha polypeptide (HGNC Symbol)
Entrez gene summary	The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Chromosome	6
Cytoband	q14.3
Chromosome location (bp)	87085498 - 87095406
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135346 (version 83.38)
Entrez gene	1081
UniProt	P01215 (UniProt - Evidence at protein level)
neXtProt	NX_P01215
Antibodypedia	CGA antibodies

PROTEIN BROWSER

CGA-001	CGA-003	CGA-004	CGA-005	CGA-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CGA-001 ENSP00000486024 ENST00000627148	P01215 [Direct mapping] Glycoprotein hormones alpha chain Q6I9S8 [Target identity:100%; Query identity:100%] CGA protein; Follicle-stimulating hormone alpha subunit; Glycoprotein hormone alpha subunit; Glycoprotein hormones, alpha polypeptide, isoform CRA_b; cDNA, FLJ92245, Homo sapiens glycoprotein hormones, alpha polypeptide (CGA), mRNA Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Show all	GO:0005179 [hormone activity] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0007165 [signal transduction] GO:0007267 [cell-cell signaling] GO:0008284 [positive regulation of cell proliferation] GO:0016486 [peptide hormone processing] GO:0030335 [positive regulation of cell migration] GO:0044267 [cellular protein metabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	116 aa 13.1 kDa	Yes	0
CGA-003 ENSP00000482232 ENST00000610310	A0A087WYZ4 [Direct mapping] Glycoprotein hormones alpha chain Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] GO:0005623 [cell] GO:0006590 [thyroid hormone generation] GO:0008406 [gonad development] GO:0030878 [thyroid gland development] GO:0032275 [luteinizing hormone secretion] GO:0032870 [cellular response to hormone stimulus] GO:0046621 [negative regulation of organ growth] GO:0046884 [follicle-stimulating hormone secretion] GO:0048589 [developmental growth] Show all	147 aa 16.3 kDa	Yes	0
CGA-004 ENSP00000486666 ENST00000625577	A0A0D9SFJ6 [Direct mapping] Glycoprotein hormones alpha chain Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	62 aa 7 kDa	Yes	0
CGA-005 ENSP00000487300 ENST00000630630	A0A0D9SGA7 [Direct mapping] Glycoprotein hormones alpha chain; Glycoprotein hormones, alpha polypeptide, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	101 aa 11.4 kDa	Yes	0
CGA-006 ENSP00000358595 ENST00000369582		Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all	GO:0005179 [hormone activity] GO:0005576 [extracellular region] Show all	116 aa 13.2 kDa	Yes	0