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LMO2

GENERAL INFORMATION

Gene name

 LMO2

Gene description

 LIM domain only 2 (rhombotin-like 1)

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, HL-60, K-562, THP-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in bone marrow and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB016258
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB016258

GENE INFORMATION

Gene name

 LMO2 (HGNC Symbol)

Synonyms

 RBTN2, RBTNL1, RHOM2, TTG2

Description

 LIM domain only 2 (rhombotin-like 1) (HGNC Symbol)

Entrez gene summary

 LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur. Alternative splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Nov 2008]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 33858576 - 33892289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135363 (version 83.38)

Entrez gene

 4005

UniProt

 P25791 (UniProt - Evidence at protein level)

neXtProt

 NX_P25791

Antibodypedia

 LMO2 antibodies

PROTEIN BROWSER
LMO2-001
LMO2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LMO2-001
ENSP00000257818
ENST00000257818
P25791 [Direct mapping]
Rhombotin-2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0035162 [embryonic hemopoiesis]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043425 [bHLH transcription factor binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048037 [cofactor binding]
GO:0070888 [E-box binding]
GO:0097067 [cellular response to thyroid hormone stimulus]
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 227 aa
25 kDa 		No 0
LMO2-002
ENSP00000379175
ENST00000395833
P25791 [Direct mapping]
Rhombotin-2
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Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001102 [RNA polymerase II activating transcription factor binding]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0007275 [multicellular organismal development]
GO:0008270 [zinc ion binding]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0043425 [bHLH transcription factor binding]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048037 [cofactor binding]
GO:0070888 [E-box binding]
GO:0097067 [cellular response to thyroid hormone stimulus]
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 158 aa
18.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.