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EHF

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GENERAL INFORMATION

Gene name

 EHF

Gene description

 Ets homologous factor

Protein class

 Predicted intracellular proteins
Predicted secreted proteins
Transcription factors

Predicted localization

 Intracellular,Secreted

Number of transcripts

 10
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

RNA cell category

 Cell line enhanced (T-47d, RT4, CAPAN-2, HaCaT)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported)

Additional location

 In addition localized to the Golgi apparatus (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050923
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (T-47d, RT4, CAPAN-2, HaCaT)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleoplasm. In addition localized to the Golgi apparatus.

Main location

 Nucleoplasm (supported)

Additional location

 Golgi apparatus (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050923 A-431 Nucleoplasm
Golgi apparatus
HPA050923 A549 Nucleoplasm
Golgi apparatus
HPA050923 U-2 OS Nucleoplasm
Golgi apparatus Intensity

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000012350 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA050923 NIH 3T3 No staining

GENE INFORMATION

Gene name

 EHF (HGNC Symbol)

Synonyms

 ESE3, ESEJ

Description

 Ets homologous factor (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to an ETS transcription factor subfamily characterized by epithelial-specific expression (ESEs). The encoded protein acts as a transcriptional repressor and may be involved in epithelial differentiation and carcinogenesis. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Chromosome

 11

Cytoband

 p13

Chromosome location (bp)

 34621093 - 34661057

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135373 (version 83.38)

Entrez gene

 26298

UniProt

 Q9NZC4 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q9NZC4

Antibodypedia

 EHF antibodies

PROTEIN BROWSER
EHF-001
EHF-002
EHF-003
EHF-004
EHF-007
EHF-008
EHF-009
EHF-010
EHF-011
EHF-012

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EHF-001
ENSP00000257831
ENST00000257831
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-002
ENSP00000433508
ENST00000530286
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-003
ENSP00000435837
ENST00000533754
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 300 aa
34.9 kDa 		No 0
EHF-004
ENSP00000435835
ENST00000531794
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
   SPOCTOPUS predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 322 aa
37.4 kDa 		Yes 0
EHF-007
ENSP00000432460
ENST00000532302
E9PQX0 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 158 aa
18.1 kDa 		No 0
EHF-008
ENSP00000436357
ENST00000531728
E9PPS9 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 126 aa
14.3 kDa 		No 0
EHF-009
ENSP00000399733
ENST00000450654
Q9NZC4 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0007275 [multicellular organismal development]
GO:0008283 [cell proliferation]
GO:0030855 [epithelial cell differentiation]
GO:0043565 [sequence-specific DNA binding]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Show all
 277 aa
32.3 kDa 		No 0
EHF-010
ENSP00000432905
ENST00000529527
E9PN75 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 166 aa
19 kDa 		No 0
EHF-011
ENSP00000434395
ENST00000525253
E9PQR6 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 173 aa
19.8 kDa 		No 0
EHF-012
ENSP00000436158
ENST00000527935
E9PPS9 [Direct mapping]
ETS homologous factor
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0043565 [sequence-specific DNA binding]
Show all
 126 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.