Expression of ATP5G2 in cancer - Summary - The Human Protein Atlas

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ATP5G2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ATP5G2
Gene description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at transcript level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Approved based on 1 antibody. HPA051469
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA051469

GENE INFORMATION
Gene name	ATP5G2
Synonyms
Description	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9) (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and single representatives of the gamma, delta, and epsilon subunits. The proton channel likely has nine subunits (a, b, c, d, e, f, g, F6 and 8). There are three separate genes which encode subunit c of the proton channel and they specify precursors with different import sequences but identical mature proteins. The protein encoded by this gene is one of three precursors of subunit c. Alternatively spliced transcript variants encoding different isoforms have been identified. This gene has multiple pseudogenes. [provided by RefSeq, Jun 2010]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53632726 - 53677408
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000135390 (version 83.38)
Entrez gene	517
UniProt	Q06055 (UniProt - Evidence at transcript level)
neXtProt	NX_Q06055
Antibodypedia	ATP5G2 antibodies

PROTEIN BROWSER

ATP5G2-002	ATP5G2-003	ATP5G2-004	ATP5G2-006	ATP5G2-007	ATP5G2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ATP5G2-002 ENSP00000340315 ENST00000338662	Q06055 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005741 [mitochondrial outer membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0008289 [lipid binding] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)] Show all	157 aa 16.3 kDa	No	2
ATP5G2-003 ENSP00000377878 ENST00000394349	Q06055 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005741 [mitochondrial outer membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0008289 [lipid binding] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)] Show all	198 aa 20.5 kDa	Yes	2
ATP5G2-004 ENSP00000448801 ENST00000552242	Q06055 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005741 [mitochondrial outer membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0008289 [lipid binding] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)] Show all	141 aa 14.6 kDa	No	2
ATP5G2-006 ENSP00000447317 ENST00000549164	Q06055 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005741 [mitochondrial outer membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0008289 [lipid binding] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)] Show all	141 aa 14.6 kDa	No	2
ATP5G2-007 ENSP00000447643 ENST00000549748	F8W041 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all		16 aa 1.8 kDa	No	0
ATP5G2-010 ENSP00000473535 ENST00000602871	Q06055 [Direct mapping] ATP synthase F(0) complex subunit C2, mitochondrial Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005215 [transporter activity] GO:0005741 [mitochondrial outer membrane] GO:0005753 [mitochondrial proton-transporting ATP synthase complex] GO:0008289 [lipid binding] GO:0015078 [hydrogen ion transmembrane transporter activity] GO:0015991 [ATP hydrolysis coupled proton transport] GO:0016021 [integral component of membrane] GO:0022904 [respiratory electron transport chain] GO:0033177 [proton-transporting two-sector ATPase complex, proton-transporting domain] GO:0042776 [mitochondrial ATP synthesis coupled proton transport] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0045263 [proton-transporting ATP synthase complex, coupling factor F(o)] Show all	141 aa 14.6 kDa	No	2

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The Human Protein Atlas

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