Expression of CD63 in cancer - Summary - The Human Protein Atlas

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CD63

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD63
Gene description	CD63 molecule
Protein class	CD markers Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in hematopoietic cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA010088 , CAB026356
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010088	CAB026356

GENE INFORMATION
Gene name	CD63 (HGNC Symbol)
Synonyms	ME491, MLA1, TSPAN30
Description	CD63 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]
Chromosome	12
Cytoband	q13.2
Chromosome location (bp)	55725323 - 55729707
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135404 (version 83.38)
Entrez gene	967
UniProt	P08962 (UniProt - Evidence at protein level)
neXtProt	NX_P08962
Antibodypedia	CD63 antibodies

PROTEIN BROWSER

CD63-001	CD63-002	CD63-003	CD63-004	CD63-006	CD63-007	CD63-008	CD63-009	CD63-010	CD63-011	CD63-012	CD63-014	CD63-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD63-001 ENSP00000447730 ENST00000549117	P08962 [Direct mapping] CD63 antigen A0A024RB05 [Target identity:100%; Query identity:100%] Tetraspanin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005737 [cytoplasm] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005770 [late endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0010633 [negative regulation of epithelial cell migration] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0030855 [epithelial cell differentiation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0032403 [protein complex binding] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0043234 [protein complex] GO:0043473 [pigmentation] GO:0045785 [positive regulation of cell adhesion] GO:0045807 [positive regulation of endocytosis] GO:0048757 [pigment granule maturation] GO:0050931 [pigment cell differentiation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	238 aa 25.6 kDa	No	4
CD63-002 ENSP00000257857 ENST00000257857	P08962 [Direct mapping] CD63 antigen A0A024RB05 [Target identity:100%; Query identity:100%] Tetraspanin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	238 aa 25.6 kDa	No	4
CD63-003 ENSP00000449337 ENST00000552692	P08962 [Direct mapping] CD63 antigen A0A024RB05 [Target identity:100%; Query identity:100%] Tetraspanin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	238 aa 25.6 kDa	No	4
CD63-004 ENSP00000446807 ENST00000552754	P08962 [Direct mapping] CD63 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	215 aa 23.4 kDa	No	3
CD63-006 ENSP00000450191 ENST00000546457	F8VNT9 [Direct mapping] CD63 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	133 aa 14.3 kDa	No	3
CD63-007 ENSP00000449281 ENST00000552164	F8VWK8 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	217 aa 23.4 kDa	No	3
CD63-008 ENSP00000446752 ENST00000551173	F8W022 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	215 aa 23.1 kDa	No	3
CD63-009 ENSP00000447356 ENST00000546939	P08962 [Direct mapping] CD63 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	156 aa 17.3 kDa	Yes	1
CD63-010 ENSP00000448091 ENST00000550776	P08962 [Direct mapping] CD63 antigen Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	156 aa 17.3 kDa	Yes	1
CD63-011 ENSP00000447938 ENST00000548898	F8VV56 [Direct mapping] CD63 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	145 aa 16 kDa	No	1
CD63-012 ENSP00000449684 ENST00000552067	F8VV56 [Direct mapping] CD63 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	145 aa 16 kDa	No	1
CD63-014 ENSP00000449654 ENST00000548160	F8VV56 [Direct mapping] CD63 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	145 aa 16 kDa	No	1
CD63-201 ENSP00000393502 ENST00000420846	P08962 [Direct mapping] CD63 antigen A0A024RB05 [Target identity:100%; Query identity:100%] Tetraspanin Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0002092 [positive regulation of receptor internalization] GO:0002576 [platelet degranulation] GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007160 [cell-matrix adhesion] GO:0007596 [blood coagulation] GO:0009986 [cell surface] GO:0010008 [endosome membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0016477 [cell migration] GO:0030168 [platelet activation] GO:0031088 [platelet dense granule membrane] GO:0031226 [intrinsic component of plasma membrane] GO:0031902 [late endosome membrane] GO:0031904 [endosome lumen] GO:0034613 [cellular protein localization] GO:0035646 [endosome to melanosome transport] GO:0042470 [melanosome] GO:0048757 [pigment granule maturation] GO:0070062 [extracellular exosome] GO:0097487 [multivesicular body, internal vesicle] GO:1900746 [regulation of vascular endothelial growth factor signaling pathway] GO:2000680 [regulation of rubidium ion transport] GO:2001046 [positive regulation of integrin-mediated signaling pathway] Show all	238 aa 25.6 kDa	No	4

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The Human Protein Atlas

The Human Protein Atlas project is funded
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