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AMHR2

GENERAL INFORMATION

Gene name

 AMHR2

Gene description

 Anti-Mullerian hormone receptor, type II

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Group enriched (HEL, K-562)
HPA (normal tissue):Tissue enhanced (adrenal gland, ovary)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 AMHR2 (HGNC Symbol)

Synonyms

 MISR2, MISRII

Description

 Anti-Mullerian hormone receptor, type II (HGNC Symbol)

Entrez gene summary

 This gene encodes the receptor for the anti-Mullerian hormone (AMH) which, in addition to testosterone, results in male sex differentiation. AMH and testosterone are produced in the testes by different cells and have different effects. Testosterone promotes the development of male genitalia while the binding of AMH to the encoded receptor prevents the development of the mullerian ducts into uterus and Fallopian tubes. Mutations in this gene are associated with persistent Mullerian duct syndrome type II. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2009]

Chromosome

 12

Cytoband

 q13.13

Chromosome location (bp)

 53423855 - 53431534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135409 (version 83.38)

Entrez gene

 269

UniProt

 Q16671 (UniProt - Evidence at protein level)

neXtProt

 NX_Q16671

Antibodypedia

 AMHR2 antibodies

PROTEIN BROWSER
AMHR2-001
AMHR2-002
AMHR2-003
AMHR2-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AMHR2-001
ENSP00000257863
ENST00000257863
Q16671 [Direct mapping]
Anti-Muellerian hormone type-2 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001880 [Mullerian duct regression]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004872 [receptor activity]
GO:0005026 [transforming growth factor beta receptor activity, type II]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007548 [sex differentiation]
GO:0008584 [male gonad development]
GO:0008585 [female gonad development]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0042562 [hormone binding]
GO:0046872 [metal ion binding]
GO:1902613 [negative regulation of anti-Mullerian hormone signaling pathway]
GO:1990262 [anti-Mullerian hormone signaling pathway]
GO:1990272 [anti-Mullerian hormone receptor activity]
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 573 aa
62.7 kDa 		Yes 1
AMHR2-002
ENSP00000369117
ENST00000379791
Q16671 [Direct mapping]
Anti-Muellerian hormone type-2 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001880 [Mullerian duct regression]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007548 [sex differentiation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0042562 [hormone binding]
GO:0046872 [metal ion binding]
Show all
 478 aa
51.8 kDa 		Yes 1
AMHR2-003
ENSP00000446661
ENST00000550311
Q16671 [Direct mapping]
Anti-Muellerian hormone type-2 receptor
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0001880 [Mullerian duct regression]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0004872 [receptor activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007548 [sex differentiation]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0042562 [hormone binding]
GO:0046872 [metal ion binding]
Show all
 478 aa
52.2 kDa 		Yes 1
AMHR2-007
ENSP00000455338
ENST00000550839
H3BPI9 [Direct mapping]
Receptor protein serine/threonine kinase
Show all
Predicted intracellular proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0006468 [protein phosphorylation]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016021 [integral component of membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
 172 aa
19.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.