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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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GDF11
  • TISSUE

  • CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

GDF11

Gene description

Growth differentiation factor 11

Protein class

Predicted secreted proteins

Predicted localization

Secreted

Number of transcripts

2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HMC-1)
HPA (normal tissue):Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression mainly in the brain and male genital system. Also expressed in peripheral nerves in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

Approved based on 1 antibody.
HPA069609
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PROGNOSTIC SUMMARY

Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA069609

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate to strong membranous positivity was observed in several cases of colorectal, breast, prostate and pancreatic cancer. A few cases of liver cancer showed strong cytoplasmic positivity. Most remaining cancer tissues were negative.

GENE INFORMATION

Gene name

GDF11 (HGNC Symbol)

Synonyms

BMP-11

Description

Growth differentiation factor 11 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development. [provided by RefSeq, Jul 2008]

Chromosome

12

Cytoband

q13.2

Chromosome location (bp)

55743280 - 55757278

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135414 (version 83.38)

Entrez gene

10220

UniProt

O95390 (UniProt - Evidence at transcript level)

neXtProt

NX_O95390

Antibodypedia

GDF11 antibodies

PROTEIN BROWSER

GDF11-001
GDF11-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

GDF11-001
ENSP00000257868
ENST00000257868
O95390 [Direct mapping]
Growth/differentiation factor 11
A0A024RB20 [Target identity:100%; Query identity:100%]
Growth differentiation factor 11, isoform CRA_a
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0001501 [skeletal system development]
GO:0001656 [metanephros development]
GO:0001657 [ureteric bud development]
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005575 [cellular_component]
GO:0005615 [extracellular space]
GO:0007399 [nervous system development]
GO:0007498 [mesoderm development]
GO:0008083 [growth factor activity]
GO:0008285 [negative regulation of cell proliferation]
GO:0009887 [organ morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0021512 [spinal cord anterior/posterior patterning]
GO:0031016 [pancreas development]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043234 [protein complex]
GO:0043408 [regulation of MAPK cascade]
GO:0045596 [negative regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0048468 [cell development]
GO:0048469 [cell maturation]
GO:0048593 [camera-type eye morphogenesis]
GO:0060021 [palate development]
GO:0060395 [SMAD protein signal transduction]
Show all
407 aa
45.1 kDa
Yes 0
GDF11-002
ENSP00000448390
ENST00000546799
H0YI30 [Direct mapping]
Growth/differentiation factor 11
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0005125 [cytokine activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005615 [extracellular space]
GO:0008083 [growth factor activity]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0040007 [growth]
GO:0042981 [regulation of apoptotic process]
GO:0043408 [regulation of MAPK cascade]
GO:0048468 [cell development]
GO:0060395 [SMAD protein signal transduction]
Show all
380 aa
42.2 kDa
Yes 0

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