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Most malignant cells showed moderate cytoplasmic positivity. Several cases of testicular and liver cancers were strongly positive. Most cervical cancers as well as cases of for example gastric and renal cancers were negative.
GENE INFORMATION
Gene name
AGAP2 (HGNC Symbol)
Synonyms
CENTG1
Description
ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the centaurin gamma-like family. It mediates anti-apoptotic effects of nerve growth factor by activating nuclear phosphoinositide 3-kinase. It is overexpressed in cancer cells, and promotes cancer cell invasion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]