Cell atlas - TFCP2 - The Human Protein Atlas

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TFCP2

TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	TFCP2
Gene description	Transcription factor CP2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (uncertain)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070247
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (uncertain)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070247	CACO-2	Nucleoplasm
	HPA070247	CACO-2	Cytosol
	HPA070247	PC-3	Nucleoplasm
	HPA070247	U-2 OS	Nucleoplasm

GENE INFORMATION
Gene name	TFCP2 (HGNC Symbol)
Synonyms	CP2, LBP-1C, LSF, TFCP2C
Description	Transcription factor CP2 (HGNC Symbol)
Entrez gene summary	This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease. [provided by RefSeq, Mar 2010]
Chromosome	12
Cytoband
Chromosome location (bp)	51093663 - 51173134
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135457 (version 83.38)
Entrez gene	7024
UniProt	Q12800 (UniProt - Evidence at protein level)
neXtProt	NX_Q12800
Antibodypedia	TFCP2 antibodies

PROTEIN BROWSER

TFCP2-001	TFCP2-002	TFCP2-004	TFCP2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TFCP2-001 ENSP00000257915 ENST00000257915	Q12800 [Direct mapping] Alpha-globin transcription factor CP2 A0A024R120 [Target identity:100%; Query identity:100%] Transcription factor CP2, isoform CRA_a Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] Show all	502 aa 57.3 kDa	No	0
TFCP2-002 ENSP00000449742 ENST00000549867	F8VX55 [Direct mapping] Alpha-globin transcription factor CP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0043565 [sequence-specific DNA binding] Show all	424 aa 48.5 kDa	No	0
TFCP2-004 ENSP00000447991 ENST00000548115	Q12800 [Direct mapping] Alpha-globin transcription factor CP2 Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008022 [protein C-terminus binding] GO:0043565 [sequence-specific DNA binding] Show all	450 aa 51.3 kDa	No	0
TFCP2-005 ENSP00000449280 ENST00000548108	F8VWL0 [Direct mapping] Alpha-globin transcription factor CP2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0043565 [sequence-specific DNA binding] Show all	381 aa 43.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.