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PAN2

GENERAL INFORMATION

Gene name

 PAN2

Gene description

 PAN2 poly(A) specific ribonuclease subunit

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 PAN2 (HGNC Symbol)

Synonyms

 hPAN2, KIAA0710, USP52

Description

 PAN2 poly(A) specific ribonuclease subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56316223 - 56334053

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000135473 (version 83.38)

Entrez gene

 9924

UniProt

 Q504Q3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q504Q3

Antibodypedia

 PAN2 antibodies

PROTEIN BROWSER
PAN2-001
PAN2-002
PAN2-003
PAN2-020
PAN2-201
PAN2-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAN2-001
ENSP00000388231
ENST00000440411
Q504Q3 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 1198 aa
135 kDa 		No 0
PAN2-002
ENSP00000257931
ENST00000257931
Q504Q3 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 1201 aa
135.3 kDa 		No 0
PAN2-003
ENSP00000449861
ENST00000548043
Q504Q3 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 1202 aa
135.4 kDa 		No 0
PAN2-020
ENSP00000449092
ENST00000547572
F8VXK8 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
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 112 aa
12.5 kDa 		No 0
PAN2-201
ENSP00000401721
ENST00000425394
Q504Q3 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 1202 aa
135.4 kDa 		No 0
PAN2-202
ENSP00000481859
ENST00000610546
Q504Q3 [Direct mapping]
PAB-dependent poly(A)-specific ribonuclease subunit PAN2
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000175 [3'-5'-exoribonuclease activity]
GO:0000288 [nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay]
GO:0000289 [nuclear-transcribed mRNA poly(A) tail shortening]
GO:0000932 [cytoplasmic mRNA processing body]
GO:0003676 [nucleic acid binding]
GO:0004535 [poly(A)-specific ribonuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005829 [cytosol]
GO:0006397 [mRNA processing]
GO:0010467 [gene expression]
GO:0010606 [positive regulation of cytoplasmic mRNA processing body assembly]
GO:0031251 [PAN complex]
GO:0090503 [RNA phosphodiester bond hydrolysis, exonucleolytic]
Show all
 1202 aa
135.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.