Expression of KRT7 in cancer - Summary - The Human Protein Atlas

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KRT7

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KRT7
Gene description	Keratin 7, type II
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (urothelial cancer)
HPA (cell line):	Cell line enhanced (A549, BEWO, RT4, SiHa)
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression mainly in glandular epithelium.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA007272 , CAB000028
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable), ovarian cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Ovarian cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (urothelial cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007272	CAB000028

GENE INFORMATION
Gene name	KRT7 (HGNC Symbol)
Synonyms	CK7, K2C7, K7, SCL
Description	Keratin 7, type II (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. The genes encoding the type II cytokeratins are clustered in a region of chromosome 12q12-q13. Alternative splicing may result in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	52232520 - 52252186
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135480 (version 83.38)
Entrez gene	3855
UniProt	P08729 (UniProt - Evidence at protein level)
neXtProt	NX_P08729
Antibodypedia	KRT7 antibodies

PROTEIN BROWSER

KRT7-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KRT7-001 ENSP00000329243 ENST00000331817	P08729 [Direct mapping] Keratin, type II cytoskeletal 7 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005882 [intermediate filament] GO:0016032 [viral process] GO:0045095 [keratin filament] GO:0070062 [extracellular exosome] Show all	469 aa 51.4 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.