Hepatocellular carcinomas, few colorectal and stomach cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were generally negative.
ACVR1B (HGNC Symbol)
ActRIB, ACVRLK4, ALK4, SKR2
Activin A receptor, type IB (HGNC Symbol)
Entrez gene summary
This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]