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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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ACVR1B
  • TISSUE

  • premium

    CELL

  • PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACVR1B

Gene description

Activin A receptor, type IB

Protein class

Cancer-related genes
Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

Intracellular,Membrane

Number of transcripts

6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including gastrointestinal.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
HPA063761
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA063761

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Hepatocellular carcinomas, few colorectal and stomach cancers showed moderate to strong cytoplasmic positivity. Remaining cancer tissues were generally negative.

GENE INFORMATION

Gene name

ACVR1B (HGNC Symbol)

Synonyms

ActRIB, ACVRLK4, ALK4, SKR2

Description

Activin A receptor, type IB (HGNC Symbol)

Entrez gene summary

This gene encodes an activin A type IB receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. This protein is a type I receptor which is essential for signaling. Mutations in this gene are associated with pituitary tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

Chromosome

12

Cytoband

q13.13

Chromosome location (bp)

51951667 - 51997078

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000135503 (version 83.38)

Entrez gene

91

UniProt

P36896 (UniProt - Evidence at protein level)

neXtProt

NX_P36896

Antibodypedia

ACVR1B antibodies

PROTEIN BROWSER

ACVR1B-001
ACVR1B-002
ACVR1B-003
ACVR1B-004
ACVR1B-005
ACVR1B-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1B-001
ENSP00000442885
ENST00000542485
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
453 aa
51.7 kDa
No 1
ACVR1B-002
ENSP00000257963
ENST00000257963
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
505 aa
56.8 kDa
Yes 1
ACVR1B-003
ENSP00000397550
ENST00000415850
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
487 aa
54.3 kDa
Yes 1
ACVR1B-004
ENSP00000442656
ENST00000541224
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0001701 [in utero embryonic development]
GO:0001942 [hair follicle development]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0007417 [central nervous system development]
GO:0009966 [regulation of signal transduction]
GO:0009986 [cell surface]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010862 [positive regulation of pathway-restricted SMAD protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046332 [SMAD binding]
GO:0046545 [development of primary female sexual characteristics]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
546 aa
61.4 kDa
Yes 1
ACVR1B-005
ENSP00000390477
ENST00000426655
P36896 [Direct mapping]
Activin receptor type-1B
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0004672 [protein kinase activity]
GO:0004674 [protein serine/threonine kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006468 [protein phosphorylation]
GO:0007165 [signal transduction]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0017002 [activin-activated receptor activity]
GO:0018107 [peptidyl-threonine phosphorylation]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030308 [negative regulation of cell growth]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032924 [activin receptor signaling pathway]
GO:0032927 [positive regulation of activin receptor signaling pathway]
GO:0034711 [inhibin binding]
GO:0038092 [nodal signaling pathway]
GO:0043235 [receptor complex]
GO:0045648 [positive regulation of erythrocyte differentiation]
GO:0046332 [SMAD binding]
GO:0046777 [protein autophosphorylation]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:0048185 [activin binding]
GO:0070062 [extracellular exosome]
GO:0097191 [extrinsic apoptotic signaling pathway]
GO:1901165 [positive regulation of trophoblast cell migration]
Show all
476 aa
53.4 kDa
Yes 1
ACVR1B-006
ENSP00000443218
ENST00000536420
F5H5Q2 [Direct mapping]
Activin receptor type-1B
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0007178 [transmembrane receptor protein serine/threonine kinase signaling pathway]
GO:0016020 [membrane]
GO:0023014 [signal transduction by protein phosphorylation]
Show all
71 aa
8.2 kDa
No 0

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