Expression of OS9 in cancer - Summary - The Human Protein Atlas

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OS9

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OS9
Gene description	Osteosarcoma amplified 9, endoplasmic reticulum lectin
Protein class	Predicted secreted proteins Transporters
Predicted localization	Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (RH-30)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA013694 , CAB011518
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013694	CAB011518

GENE INFORMATION
Gene name	OS9 (HGNC Symbol)
Synonyms	ERLEC2, OS-9
Description	Osteosarcoma amplified 9, endoplasmic reticulum lectin (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that is highly expressed in osteosarcomas. This protein binds to the hypoxia-inducible factor 1 (HIF-1), a key regulator of the hypoxic response and angiogenesis, and promotes the degradation of one of its subunits. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband
Chromosome location (bp)	57693955 - 57721557
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135506 (version 83.38)
Entrez gene	10956
UniProt	Q13438 (UniProt - Evidence at protein level)
neXtProt	NX_Q13438
Antibodypedia	OS9 antibodies

PROTEIN BROWSER

OS9-001	OS9-002	OS9-003	OS9-005	OS9-006	OS9-007	OS9-008	OS9-009	OS9-018	OS9-019	OS9-020

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OS9-001 ENSP00000318165 ENST00000315970	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0002020 [protease binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006605 [protein targeting] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	667 aa 75.6 kDa	Yes	0
OS9-002 ENSP00000450010 ENST00000552285	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	612 aa 69.2 kDa	Yes	0
OS9-003 ENSP00000407360 ENST00000439210	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	538 aa 60.8 kDa	Yes	0
OS9-005 ENSP00000257966 ENST00000257966	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	613 aa 69.3 kDa	Yes	0
OS9-006 ENSP00000373798 ENST00000389146	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	652 aa 73.8 kDa	Yes	0
OS9-007 ENSP00000413112 ENST00000413095	B4E321 [Direct mapping] Protein OS-9; cDNA FLJ58567, highly similar to Homo sapiens amplified in osteosarcoma (OS9), transcript variant 2, mRNA Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		406 aa 46.3 kDa	Yes	0
OS9-008 ENSP00000447866 ENST00000551035	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	580 aa 65.5 kDa	Yes	0
OS9-009 ENSP00000389632 ENST00000435406	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	560 aa 63.2 kDa	Yes	0
OS9-018 ENSP00000447719 ENST00000550372	F8VZI7 [Direct mapping] Protein OS-9 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		162 aa 17.6 kDa	Yes	0
OS9-019 ENSP00000447031 ENST00000547079	F8W1V2 [Direct mapping] Protein OS-9 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 21 kDa	Yes	0
OS9-020 ENSP00000373794 ENST00000389142	Q13438 [Direct mapping] Protein OS-9 Show all	Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000836 [Hrd1p ubiquitin ligase complex] GO:0001948 [glycoprotein binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0006621 [protein retention in ER lumen] GO:0016567 [protein ubiquitination] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0030246 [carbohydrate binding] GO:0030433 [ER-associated ubiquitin-dependent protein catabolic process] GO:0034976 [response to endoplasmic reticulum stress] GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:1904153 [negative regulation of retrograde protein transport, ER to cytosol] Show all	597 aa 67.5 kDa	Yes	0

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