Expression of LTV1 in cancer - Summary - The Human Protein Atlas

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LTV1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTV1
Gene description	LTV1 ribosome biogenesis factor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA030159 , HPA030160 , HPA030161
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030159	HPA030160	HPA030161

GENE INFORMATION
Gene name	LTV1 (HGNC Symbol)
Synonyms	C6orf93, dJ468K18.4, FLJ14909
Description	LTV1 ribosome biogenesis factor (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q24.2
Chromosome location (bp)	143843344 - 143863812
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135521 (version 83.38)
Entrez gene	84946
UniProt	Q96GA3 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GA3
Antibodypedia	LTV1 antibodies

PROTEIN BROWSER

LTV1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTV1-001 ENSP00000356548 ENST00000367576	Q96GA3 [Direct mapping] Protein LTV1 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	475 aa 54.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.