Expression of CD164 in cancer - Summary - The Human Protein Atlas

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CD164

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD164
Gene description	CD164 molecule, sialomucin
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA010636
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA010636

GENE INFORMATION
Gene name	CD164 (HGNC Symbol)
Synonyms	DFNA66, MGC-24, MUC-24
Description	CD164 molecule, sialomucin (HGNC Symbol)
Entrez gene summary	Sialomucins are a heterogeneous group of secreted or membrane-associated mucins that appear to play 2 key but opposing roles in vivo: first as cytoprotective or antiadhesive agents, and second as adhesion receptors. CD164 is a type I integral transmembrane sialomucin that functions as an adhesion receptor (Watt et al., 1998 [PubMed 9680353]; Forde et al., 2007 [PubMed 17077324]).[supplied by OMIM, Aug 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	109366514 - 109382559
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135535 (version 83.38)
Entrez gene	8763
UniProt	Q04900 (UniProt - Evidence at protein level)
neXtProt	NX_Q04900
Antibodypedia	CD164 antibodies

PROTEIN BROWSER

CD164-001	CD164-002	CD164-003	CD164-004	CD164-005	CD164-007	CD164-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD164-001 ENSP00000402237 ENST00000413644	Q04900 [Direct mapping] Sialomucin core protein 24 Show all	CD markers MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0030097 [hemopoiesis] Show all	189 aa 20 kDa	Yes	0
CD164-002 ENSP00000314177 ENST00000324953	Q04900 [Direct mapping] Sialomucin core protein 24 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0030097 [hemopoiesis] Show all	178 aa 19 kDa	Yes	1
CD164-003 ENSP00000309376 ENST00000310786	Q04900 [Direct mapping] Sialomucin core protein 24 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0030097 [hemopoiesis] Show all	197 aa 20.9 kDa	Yes	1
CD164-004 ENSP00000275080 ENST00000275080	Q04900 [Direct mapping] Sialomucin core protein 24 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0030097 [hemopoiesis] Show all	184 aa 19.7 kDa	Yes	1
CD164-005 ENSP00000422999 ENST00000504373	D6R9B4 [Direct mapping] Sialomucin core protein 24 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	163 aa 17.7 kDa	No	1
CD164-007 ENSP00000427546 ENST00000512821	Q04900 [Direct mapping] Sialomucin core protein 24 Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005764 [lysosome] GO:0005765 [lysosomal membrane] GO:0005768 [endosome] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007157 [heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules] GO:0007162 [negative regulation of cell adhesion] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0007517 [muscle organ development] GO:0008285 [negative regulation of cell proliferation] GO:0010008 [endosome membrane] GO:0030097 [hemopoiesis] Show all	157 aa 16.7 kDa	Yes	0
CD164-201 ENSP00000357957 ENST00000368961	Q5JSU3 [Direct mapping] CD164 variant C; Sialomucin core protein 24 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		147 aa 15.9 kDa	Yes	0

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The Human Protein Atlas

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