Expression of LACE1 in cancer - Summary - The Human Protein Atlas

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LACE1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LACE1
Gene description	Lactation elevated 1
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Mainly cytoplasmic expression at variable levels in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 3 antibodies. HPA030154 , HPA030155 , HPA030659
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030154	HPA030155	HPA030659

GENE INFORMATION
Gene name	LACE1 (HGNC Symbol)
Synonyms	AFG1
Description	Lactation elevated 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with possible ATPase function. The protein contains a P-loop motif and a five-domain structure that is conserved in fly, yeast, and bacteria. Two conserved estrogen receptor binding sites are located within 2.5 kb of this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q21
Chromosome location (bp)	108294894 - 108526796
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135537 (version 83.38)
Entrez gene	246269
UniProt	Q8WV93 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WV93
Antibodypedia	LACE1 antibodies

PROTEIN BROWSER

LACE1-001	LACE1-006	LACE1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LACE1-001 ENSP00000357973 ENST00000368977	Q8WV93 [Direct mapping] Lactation elevated protein 1 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005739 [mitochondrion] Show all	481 aa 54.8 kDa	Yes	0
LACE1-006 ENSP00000398225 ENST00000421954	H0Y5F4 [Direct mapping] Lactation elevated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	349 aa 40.3 kDa	No	0
LACE1-007 ENSP00000392085 ENST00000437715	A6ZJA2 [Direct mapping] Lactation elevated protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	160 aa 18.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.