Expression of NHSL1 in cancer - Summary - The Human Protein Atlas

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NHSL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NHSL1
Gene description	NHS-like 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (TIME)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 3 antibodies. HPA029966 , HPA029967 , HPA029968
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA029966	HPA029967	HPA029968

GENE INFORMATION
Gene name	NHSL1 (HGNC Symbol)
Synonyms	bA43P8.1, C6orf63, KIAA1357
Description	NHS-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q24.1
Chromosome location (bp)	138422043 - 138692571
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135540 (version 83.38)
Entrez gene	57224
UniProt	Q5SYE7 (UniProt - Evidence at protein level)
neXtProt	NX_Q5SYE7
Antibodypedia	NHSL1 antibodies

PROTEIN BROWSER

NHSL1-001	NHSL1-002	NHSL1-003	NHSL1-008	NHSL1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NHSL1-001 ENSP00000394546 ENST00000427025	Q5SYE7 [Direct mapping] NHS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		1610 aa 170.7 kDa	No	0
NHSL1-002 ENSP00000344672 ENST00000343505	Q5SYE7 [Direct mapping] NHS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all		1606 aa 170.5 kDa	No	0
NHSL1-003 ENSP00000433523 ENST00000491526	H0YDF6 [Direct mapping] NHS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		169 aa 19.2 kDa	No	0
NHSL1-008 ENSP00000434958 ENST00000533765	E9PMJ0 [Direct mapping] NHS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		137 aa 15.8 kDa	No	0
NHSL1-009 ENSP00000344582 ENST00000342260	E9PAK2 [Direct mapping] NHS-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		221 aa 25.1 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.