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Moderate to strong cytoplasmic immunoreactivity was displayed in prostate cancers. A few thyroid cancers were moderately positive. The remaining malignant tissues were in general negative.
Weak to moderate cytoplasmic positivity was seen in most malignant tissues. Urothelial cancers were strongly stained. Skin, stomach and liver cancers were negative.
This gene encodes a protein which was initially identified as a sphingomyelinase based on sequence similarity between bacterial sphingomyelinases and a yeast protein. Subsequent studies showed that its biological function is less likely to be as a sphingomyelinase and instead as a lysophospholipase. [provided by RefSeq, Oct 2009]