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Colorectal cancers and lymphomas displayed strong cytoplasmic immunoreactivity. Most other cancer tissues showed weak to moderate staining.
GENE INFORMATION
Gene name
TEC (HGNC Symbol)
Synonyms
PSCTK4
Description
Tec protein tyrosine kinase (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Enzymes ENZYME proteins Transferases Kinases Tyr protein kinases Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)