Cell atlas - CCT7 - The Human Protein Atlas

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CCT7

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CCT7
Gene description	Chaperonin containing TCP1, subunit 7 (eta)
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA008425
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA008425	A-431	Cytosol
	HPA008425	U-2 OS	Cytosol
	HPA008425	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CCT7 (HGNC Symbol)
Synonyms	Ccth, Nip7-1
Description	Chaperonin containing TCP1, subunit 7 (eta) (HGNC Symbol)
Entrez gene summary	This gene encodes a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 5 and 6. [provided by RefSeq, Oct 2009]
Chromosome	2
Cytoband	p13.2
Chromosome location (bp)	73233420 - 73253021
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000135624 (version 83.38)
Entrez gene	10574
UniProt	Q99832 (UniProt - Evidence at protein level)
neXtProt	NX_Q99832
Antibodypedia	CCT7 antibodies

PROTEIN BROWSER

CCT7-001	CCT7-003	CCT7-010	CCT7-201	CCT7-202	CCT7-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCT7-001 ENSP00000258091 ENST00000258091	Q99832 [Direct mapping] T-complex protein 1 subunit eta T-complex protein 1 subunit eta, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002199 [zona pellucida receptor complex] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0005832 [chaperonin-containing T-complex] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0007339 [binding of sperm to zona pellucida] GO:0042802 [identical protein binding] GO:0044267 [cellular protein metabolic process] GO:0044297 [cell body] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0070062 [extracellular exosome] GO:1901998 [toxin transport] Show all	543 aa 59.4 kDa	No	0
CCT7-003 ENSP00000412996 ENST00000399032	F8WAM2 [Direct mapping] T-complex protein 1 subunit eta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	98 aa 10.5 kDa	No	0
CCT7-010 ENSP00000381456 ENST00000398422	Q99832 [Direct mapping] T-complex protein 1 subunit eta T-complex protein 1 subunit eta, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005832 [chaperonin-containing T-complex] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0070062 [extracellular exosome] Show all	339 aa 37.5 kDa	No	0
CCT7-201 ENSP00000437824 ENST00000539919	Q99832 [Direct mapping] T-complex protein 1 subunit eta T-complex protein 1 subunit eta, N-terminally processed Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005832 [chaperonin-containing T-complex] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0070062 [extracellular exosome] Show all	499 aa 54.8 kDa	No	0
CCT7-202 ENSP00000442058 ENST00000540468	Q99832 [Direct mapping] T-complex protein 1 subunit eta T-complex protein 1 subunit eta, N-terminally processed Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005832 [chaperonin-containing T-complex] GO:0005874 [microtubule] GO:0006457 [protein folding] GO:0044267 [cellular protein metabolic process] GO:0051082 [unfolded protein binding] GO:0051084 ['de novo' posttranslational protein folding] GO:0070062 [extracellular exosome] Show all	456 aa 50.4 kDa	No	0
CCT7-203 ENSP00000487267 ENST00000626868	A0A0D9SG95 [Direct mapping] T-complex protein 1 subunit eta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	83 aa 8.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.