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EGR4

GENERAL INFORMATION

Gene name

 EGR4

Gene description

 Early growth response 4

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (cerebral cortex, testis)
GTEx:Tissue enhanced (cerebellum)
FANTOM5:Tissue enhanced (caudate, cerebellum, hippocampus)

Protein evidence

 Evidence at transcript level

Protein expression

 Cytoplasmic and nuclear expression mainly in subsets of cells in the CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA028983
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, testis)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (caudate, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 EGR4 (HGNC Symbol)

Synonyms

 NGFI-C, PAT133

Description

 Early growth response 4 (HGNC Symbol)

Entrez gene summary

Chromosome

 2

Cytoband

 p13.2

Chromosome location (bp)

 73290929 - 73293705

Protein evidence

 Evidence at transcript level (all genes)

Ensembl

 ENSG00000135625 (version 83.38)

Entrez gene

 1961

UniProt

 Q05215 (UniProt - Evidence at transcript level)

neXtProt

 NX_Q05215

Antibodypedia

 EGR4 antibodies

PROTEIN BROWSER
EGR4-001
EGR4-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
EGR4-001
ENSP00000419687
ENST00000436467
A0A0C4DG96 [Direct mapping]
Early growth response protein 4
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
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 486 aa
50.8 kDa 		No 0
EGR4-201
ENSP00000445626
ENST00000545030
Q05215 [Direct mapping]
Early growth response protein 4
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
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GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008284 [positive regulation of cell proliferation]
GO:0043066 [negative regulation of apoptotic process]
GO:0046872 [metal ion binding]
GO:0071320 [cellular response to cAMP]
GO:0071371 [cellular response to gonadotropin stimulus]
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 589 aa
61.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.